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Breast cancers showed moderate to strong cytoplasmic positivity. The majority of cancer cells displayed weak to moderate cytoplasmic immunoreactivity. Lymphomas along with several gliomas, melanomas, endometrial and prostate cancers were negative.
GENE INFORMATION
Gene name
PGAP3 (HGNC Symbol)
Synonyms
CAB2, MGC9753, PER1, PERLD1, PP1498
Description
Post-GPI attachment to proteins 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause the autosomal recessive neurologic disorder hyperphosphatasia with mental retardation syndrome 4 (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]
