Cell atlas - PGAP3 - The Human Protein Atlas

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PGAP3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PGAP3
Gene description	Post-GPI attachment to proteins 3
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Cell line enhanced (SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA016591
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA016591	A-431	Plasma membrane
	HPA016591	A-431	Cytosol
	HPA016591	U-2 OS	No staining
	HPA016591	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PGAP3 (HGNC Symbol)
Synonyms	CAB2, MGC9753, PER1, PERLD1, PP1498
Description	Post-GPI attachment to proteins 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause the autosomal recessive neurologic disorder hyperphosphatasia with mental retardation syndrome 4 (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	39671122 - 39696797
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161395 (version 83.38)
Entrez gene	93210
UniProt	Q96FM1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96FM1
Antibodypedia	PGAP3 antibodies

PROTEIN BROWSER

PGAP3-001	PGAP3-002	PGAP3-003	PGAP3-004	PGAP3-006	PGAP3-201	PGAP3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGAP3-001 ENSP00000300658 ENST00000300658	Q96FM1 [Direct mapping] Post-GPI attachment to proteins factor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Show all	GO:0000139 [Golgi membrane] GO:0006505 [GPI anchor metabolic process] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0031227 [intrinsic component of endoplasmic reticulum membrane] Show all	320 aa 36.5 kDa	Yes	7
PGAP3-002 ENSP00000367250 ENST00000378011	Q96FM1 [Direct mapping] Post-GPI attachment to proteins factor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Show all	GO:0000139 [Golgi membrane] GO:0006505 [GPI anchor metabolic process] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0031227 [intrinsic component of endoplasmic reticulum membrane] Show all	269 aa 30.7 kDa	Yes	5
PGAP3-003 ENSP00000463234 ENST00000579146	J3QKU0 [Direct mapping] Post-GPI attachment to proteins factor 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		148 aa 16.5 kDa	Yes	0
PGAP3-004 ENSP00000415765 ENST00000429199	Q96FM1 [Direct mapping] Post-GPI attachment to proteins factor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Show all	GO:0000139 [Golgi membrane] GO:0006505 [GPI anchor metabolic process] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0031227 [intrinsic component of endoplasmic reticulum membrane] Show all	299 aa 34 kDa	Yes	6
PGAP3-006 ENSP00000463785 ENST00000584856	J3QQL0 [Direct mapping] Post-GPI attachment to proteins factor 3 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	70 aa 8 kDa	No	0
PGAP3-201 ENSP00000480165 ENST00000614824	A0A087WWE5 [Direct mapping] Post-GPI attachment to proteins factor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	319 aa 36.2 kDa	Yes	6
PGAP3-202 ENSP00000478028 ENST00000619169	A0A087WTP0 [Direct mapping] Post-GPI attachment to proteins factor 3 Show all	Predicted intracellular proteins Show all		240 aa 25.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.