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A majority of cancers displayed moderate nuclear positivity. Several malignant melanomas, pancreatic and liver cancers were strongly stained. Malignant carcinoids and prostate cancers were generally negative.
A majority of malignant cells showed moderate nuclear and cytoplasmic staining. Several cases of malignant glioma and lymphoma were negative. Most prostate cancers were negative.
GENE INFORMATION
Gene name
RBM15 (HGNC Symbol)
Synonyms
OTT, OTT1
Description
RNA binding motif protein 15 (HGNC Symbol)
Entrez gene summary
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Q96T37 [Direct mapping] Putative RNA-binding protein 15
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Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0001569 [patterning of blood vessels] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0007221 [positive regulation of transcription of Notch receptor target] GO:0016032 [viral process] GO:0016607 [nuclear speck] GO:0031965 [nuclear membrane] GO:0044822 [poly(A) RNA binding] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0048536 [spleen development] GO:0060412 [ventricular septum morphogenesis] GO:0060674 [placenta blood vessel development]
Q96T37 [Direct mapping] Putative RNA-binding protein 15
Show all
Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q96T37 [Direct mapping] Putative RNA-binding protein 15
Show all
Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
A0A087WWP4 [Direct mapping] Putative RNA-binding protein 15
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Q96T37 [Direct mapping] Putative RNA-binding protein 15
Show all
Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
