Cell atlas - RBM15 - The Human Protein Atlas

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RBM15

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RBM15
Gene description	RNA binding motif protein 15
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)

DATA RELIABILITY
Reliability score	Validated based on 3 antibodies. CAB015201 , HPA019824 , HPA049642
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB015201	A-431	Nucleoplasm
	CAB015201	U-2 OS	Nucleoplasm
	CAB015201	U-251 MG	Nucleoplasm
	HPA019824	A-431	Nucleoplasm
	HPA019824	U-2 OS	Nucleoplasm
	HPA019824	U-251 MG	Nucleoplasm
	HPA049642	A-431	Nucleoplasm
	HPA049642	U-2 OS	Nucleoplasm
	HPA049642	U-251 MG	Nucleoplasm

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000048109 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA049642	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	RBM15 (HGNC Symbol)
Synonyms	OTT, OTT1
Description	RNA binding motif protein 15 (HGNC Symbol)
Entrez gene summary	Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	110338506 - 110346681
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162775 (version 83.38)
Entrez gene	64783
UniProt	Q96T37 (UniProt - Evidence at protein level)
neXtProt	NX_Q96T37
Antibodypedia	RBM15 antibodies

PROTEIN BROWSER

RBM15-001	RBM15-002	RBM15-003	RBM15-004	RBM15-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RBM15-001 ENSP00000358799 ENST00000369784	Q96T37 [Direct mapping] Putative RNA-binding protein 15 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0001569 [patterning of blood vessels] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0007221 [positive regulation of transcription of Notch receptor target] GO:0016032 [viral process] GO:0016607 [nuclear speck] GO:0031965 [nuclear membrane] GO:0044822 [poly(A) RNA binding] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0048536 [spleen development] GO:0060412 [ventricular septum morphogenesis] GO:0060674 [placenta blood vessel development] Show all	977 aa 107.2 kDa	No	0
RBM15-002 ENSP00000473552 ENST00000487146	Q96T37 [Direct mapping] Putative RNA-binding protein 15 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0016032 [viral process] GO:0016607 [nuclear speck] GO:0031965 [nuclear membrane] GO:0044822 [poly(A) RNA binding] Show all	969 aa 106.4 kDa	No	0
RBM15-003 ENSP00000473638 ENST00000602849	Q96T37 [Direct mapping] Putative RNA-binding protein 15 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0016032 [viral process] GO:0016607 [nuclear speck] GO:0031965 [nuclear membrane] GO:0044822 [poly(A) RNA binding] Show all	957 aa 104.8 kDa	No	0
RBM15-004 ENSP00000480399 ENST00000617047	A0A087WWP4 [Direct mapping] Putative RNA-binding protein 15 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	933 aa 102.1 kDa	No	0
RBM15-201 ENSP00000483133 ENST00000618772	Q96T37 [Direct mapping] Putative RNA-binding protein 15 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0016032 [viral process] GO:0016607 [nuclear speck] GO:0031965 [nuclear membrane] GO:0044822 [poly(A) RNA binding] Show all	977 aa 107.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.