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Distinct cytoplasmic and membranous staining was observed in testicular cancers as well as cases of endometrial cancers. Fractions of cells in cases of ovarian, cervical and gastric cancers exhibited moderate to strong cytoplasmic and membranous staining. Remaining cancers were negative.
Several cases of hepatocellular carcinomas and endometrial cancers along with a case of gastric cancer displayed strong cytoplasmic positivity. A few testicular cancers showed moderate cytoplasmic and membranous staining. Remaining cancers were negative.
Cases of seminomas, endometrial and ovarian cancers displayed moderate to strong luminal membranous and cytoplasmic immunoreactivity. Remaining cancers were negative.
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]
