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ALPPL2

GENERAL INFORMATION

Gene name

 ALPPL2

Gene description

 Alkaline phosphatase, placental-like 2

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (fallopian tube, cervix, uterine)
GTEx:Not detected
FANTOM5:Tissue enhanced (lung)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in placental trophoblasts.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA038764 , HPA038765 , HPA051699 , CAB020698
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (fallopian tube, cervix, uterine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION

Gene name

 ALPPL2

Synonyms

Description

 Alkaline phosphatase, placental-like 2 (HGNC Symbol)

Entrez gene summary

 There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 232406843 - 232410714

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163286 (version 83.38)

Entrez gene

 251

UniProt

 P10696 (UniProt - Evidence at transcript level)

neXtProt

 NX_P10696

Antibodypedia

 ALPPL2 antibodies

PROTEIN BROWSER
ALPPL2-001
ALPPL2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALPPL2-001
ENSP00000295453
ENST00000295453
P10696 [Direct mapping]
Alkaline phosphatase, placental-like
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
GO:0046872 [metal ion binding]
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 532 aa
57.4 kDa 		Yes 0
ALPPL2-201
ENSP00000483564
ENST00000611550
A0A087X0P5 [Direct mapping]
Alkaline phosphatase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
Show all
 531 aa
57.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.