Cell atlas - ALPPL2 - The Human Protein Atlas

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ALPPL2

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ALPPL2
Gene description	Alkaline phosphatase, placental-like 2
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Group enriched (CAPAN-2, HaCaT, BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA038764
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (CAPAN-2, HaCaT, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038764	HeLa	Plasma membrane
	HPA038764	SiHa	No staining
	HPA038764	U-2 OS	No staining

GENE INFORMATION
Gene name	ALPPL2
Synonyms
Description	Alkaline phosphatase, placental-like 2 (HGNC Symbol)
Entrez gene summary	There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	232406843 - 232410714
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163286 (version 83.38)
Entrez gene	251
UniProt	P10696 (UniProt - Evidence at transcript level)
neXtProt	NX_P10696
Antibodypedia	ALPPL2 antibodies

PROTEIN BROWSER

ALPPL2-001	ALPPL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALPPL2-001 ENSP00000295453 ENST00000295453	P10696 [Direct mapping] Alkaline phosphatase, placental-like Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004035 [alkaline phosphatase activity] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0031225 [anchored component of membrane] GO:0046872 [metal ion binding] Show all	532 aa 57.4 kDa	Yes	0
ALPPL2-201 ENSP00000483564 ENST00000611550	A0A087X0P5 [Direct mapping] Alkaline phosphatase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004035 [alkaline phosphatase activity] GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	531 aa 57.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.