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Malignant tissues displayed moderate cytoplasmic positivity. Additional membranous staining was observed in colorectal and pancreatic cancers. A few cases of breast, ovarian, gastric and pancreatic cancers were strongly stained.
GENE INFORMATION
Gene name
GABRB1
Synonyms
Description
Gamma-aminobutyric acid (GABA) A receptor, beta 1 (HGNC Symbol)
Entrez gene summary
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]