Fields »
ABOUT
HELP
BLOG
GABRB1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 GABRB1

Gene description

 Gamma-aminobutyric acid (GABA) A receptor, beta 1

Protein class

 FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-87 MG, REH)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG, REH)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GABRB1

Synonyms

Description

 Gamma-aminobutyric acid (GABA) A receptor, beta 1 (HGNC Symbol)

Entrez gene summary

 The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p12

Chromosome location (bp)

 46993723 - 47426444

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163288 (version 83.38)

Entrez gene

 2560

UniProt

 P18505 (UniProt - Evidence at transcript level)

neXtProt

 NX_P18505

Antibodypedia

 GABRB1 antibodies

PROTEIN BROWSER
GABRB1-001
GABRB1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GABRB1-001
ENSP00000295454
ENST00000295454
P18505 [Direct mapping]
Gamma-aminobutyric acid receptor subunit beta-1
X5DNL6 [Target identity:100%; Query identity:100%]
Gamma-aminobutyric acid A receptor beta 1 isoform A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005253 [anion channel activity]
GO:0005254 [chloride channel activity]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0009636 [response to toxic substance]
GO:0015276 [ligand-gated ion channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0021954 [central nervous system neuron development]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032570 [response to progesterone]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0042698 [ovulation cycle]
GO:0043005 [neuron projection]
GO:0043235 [receptor complex]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050811 [GABA receptor binding]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0071420 [cellular response to histamine]
GO:1902476 [chloride transmembrane transport]
GO:1902711 [GABA-A receptor complex]
Show all
 474 aa
54.2 kDa 		Yes 4
GABRB1-005
ENSP00000426753
ENST00000513567
D6REM0 [Direct mapping]
Gamma-aminobutyric acid receptor subunit beta-1
Show all
Predicted intracellular proteins
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
Show all
 117 aa
13.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.