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GABRB1

GENERAL INFORMATION

Gene name

 GABRB1

Gene description

 Gamma-aminobutyric acid (GABA) A receptor, beta 1

Protein class

 FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebral cortex, pituitary gland, hypothalamus, hippocampus, cerebellum)
FANTOM5:Group enriched (caudate, pituitary gland, hippocampus, cerebellum, brain)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA051297
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebral cortex, pituitary gland, hypothalamus, hippocampus, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, pituitary gland, hippocampus, cerebellum, brain)

GENE INFORMATION

Gene name

 GABRB1

Synonyms

Description

 Gamma-aminobutyric acid (GABA) A receptor, beta 1 (HGNC Symbol)

Entrez gene summary

 The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p12

Chromosome location (bp)

 46993723 - 47426444

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163288 (version 83.38)

Entrez gene

 2560

UniProt

 P18505 (UniProt - Evidence at transcript level)

neXtProt

 NX_P18505

Antibodypedia

 GABRB1 antibodies

PROTEIN BROWSER
GABRB1-001
GABRB1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GABRB1-001
ENSP00000295454
ENST00000295454
P18505 [Direct mapping]
Gamma-aminobutyric acid receptor subunit beta-1
X5DNL6 [Target identity:100%; Query identity:100%]
Gamma-aminobutyric acid A receptor beta 1 isoform A
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
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GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005253 [anion channel activity]
GO:0005254 [chloride channel activity]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0009636 [response to toxic substance]
GO:0015276 [ligand-gated ion channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0021954 [central nervous system neuron development]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032570 [response to progesterone]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0042698 [ovulation cycle]
GO:0043005 [neuron projection]
GO:0043235 [receptor complex]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050811 [GABA receptor binding]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0071420 [cellular response to histamine]
GO:1902476 [chloride transmembrane transport]
GO:1902711 [GABA-A receptor complex]
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 474 aa
54.2 kDa 		Yes 4
GABRB1-005
ENSP00000426753
ENST00000513567
D6REM0 [Direct mapping]
Gamma-aminobutyric acid receptor subunit beta-1
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Predicted intracellular proteins
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GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
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 117 aa
13.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.