We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancer tissues showed weak to moderate cytoplasmic positivity with additional membranous staining seen in colorectal and pancreatic cancers. Few adenocarcinomas of lung and a single case of papillary adenocarcinoma of thyroid exhibited strong immunoreactivity. Lymphomas were negative.
GENE INFORMATION
Gene name
RNF123 (HGNC Symbol)
Synonyms
FLJ12565
Description
Ring finger protein 123 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. [provided by RefSeq, Feb 2012]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
