Cell atlas - RNF123 - The Human Protein Atlas

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RNF123

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	RNF123
Gene description	Ring finger protein 123
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071879
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071879	PC-3	Cytosol

GENE INFORMATION
Gene name	RNF123 (HGNC Symbol)
Synonyms	FLJ12565
Description	Ring finger protein 123 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. [provided by RefSeq, Feb 2012]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49689499 - 49721529
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164068 (version 83.38)
Entrez gene	63891
UniProt	Q5XPI4 (UniProt - Evidence at protein level)
neXtProt	NX_Q5XPI4
Antibodypedia	RNF123 antibodies

PROTEIN BROWSER

RNF123-001	RNF123-002	RNF123-007	RNF123-008	RNF123-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF123-001 ENSP00000328287 ENST00000327697	Q5XPI4 [Direct mapping] E3 ubiquitin-protein ligase RNF123 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	1314 aa 148.5 kDa	No	0
RNF123-002 ENSP00000392443 ENST00000432042	C9J266 [Direct mapping] E3 ubiquitin-protein ligase RNF123 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	762 aa 86.8 kDa	No	0
RNF123-007 ENSP00000416156 ENST00000433785	C9JI97 [Direct mapping] E3 ubiquitin-protein ligase RNF123 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	426 aa 47.7 kDa	No	0
RNF123-008 ENSP00000408490 ENST00000454491	C9JN91 [Direct mapping] E3 ubiquitin-protein ligase RNF123 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8.5 kDa	No	0
RNF123-201 ENSP00000487104 ENST00000629802	F8WB91 [Direct mapping] E3 ubiquitin-protein ligase RNF123 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.