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HPGD

GENERAL INFORMATION

Gene name

 HPGD

Gene description

 Hydroxyprostaglandin dehydrogenase 15-(NAD)

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (urinary bladder)
GTEx:Tissue enhanced (urinary bladder)
FANTOM5:Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different cell types, including urothelial cells and surface epithelium of the gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA004919 , HPA005679
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (urinary bladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (urinary bladder)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION

Gene name

 HPGD (HGNC Symbol)

Synonyms

 SDR36C1

Description

 Hydroxyprostaglandin dehydrogenase 15-(NAD) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

 4

Cytoband

 q34.1

Chromosome location (bp)

 174490177 - 174523154

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164120 (version 83.38)

Entrez gene

 3248

UniProt

 P15428 (UniProt - Evidence at protein level)

neXtProt

 NX_P15428

Antibodypedia

 HPGD antibodies

PROTEIN BROWSER
HPGD-001
HPGD-002
HPGD-004
HPGD-008
HPGD-010
HPGD-011
HPGD-013
HPGD-201
HPGD-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HPGD-001
ENSP00000296522
ENST00000296522
P15428 [Direct mapping]
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005829 [cytosol]
GO:0006693 [prostaglandin metabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007565 [female pregnancy]
GO:0007567 [parturition]
GO:0008152 [metabolic process]
GO:0016323 [basolateral plasma membrane]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016491 [oxidoreductase activity]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0019372 [lipoxygenase pathway]
GO:0030728 [ovulation]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070403 [NAD+ binding]
GO:0070493 [thrombin receptor signaling pathway]
GO:0097070 [ductus arteriosus closure]
GO:2001300 [lipoxin metabolic process]
Show all
 266 aa
29 kDa 		No 0
HPGD-002
ENSP00000422418
ENST00000510901
P15428 [Direct mapping]
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005829 [cytosol]
GO:0006693 [prostaglandin metabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007565 [female pregnancy]
GO:0007567 [parturition]
GO:0008152 [metabolic process]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016491 [oxidoreductase activity]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0019372 [lipoxygenase pathway]
GO:0030728 [ovulation]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070403 [NAD+ binding]
GO:0070493 [thrombin receptor signaling pathway]
GO:0097070 [ductus arteriosus closure]
GO:2001300 [lipoxin metabolic process]
Show all
 145 aa
15.7 kDa 		No 0
HPGD-004
ENSP00000420892
ENST00000504433
E9PBZ2 [Direct mapping]
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 176 aa
19.1 kDa 		No 0
HPGD-008
ENSP00000423066
ENST00000506910
D6RA83 [Direct mapping]
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 99 aa
10.7 kDa 		No 0
HPGD-010
ENSP00000423110
ENST00000514584
D6RA66 [Direct mapping]
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 97 aa
10.5 kDa 		No 0
HPGD-011
ENSP00000398720
ENST00000422112
P15428 [Direct mapping]
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005829 [cytosol]
GO:0006693 [prostaglandin metabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007565 [female pregnancy]
GO:0007567 [parturition]
GO:0008152 [metabolic process]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016491 [oxidoreductase activity]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0019372 [lipoxygenase pathway]
GO:0030728 [ovulation]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070403 [NAD+ binding]
GO:0070493 [thrombin receptor signaling pathway]
GO:0097070 [ductus arteriosus closure]
GO:2001300 [lipoxin metabolic process]
Show all
 198 aa
21.5 kDa 		No 0
HPGD-013
ENSP00000296521
ENST00000296521
P15428 [Direct mapping]
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005829 [cytosol]
GO:0006693 [prostaglandin metabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007565 [female pregnancy]
GO:0007567 [parturition]
GO:0008152 [metabolic process]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016491 [oxidoreductase activity]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0019372 [lipoxygenase pathway]
GO:0030728 [ovulation]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070403 [NAD+ binding]
GO:0070493 [thrombin receptor signaling pathway]
GO:0097070 [ductus arteriosus closure]
GO:2001300 [lipoxin metabolic process]
Show all
 178 aa
19.3 kDa 		No 0
HPGD-201
ENSP00000438017
ENST00000541923
P15428 [Direct mapping]
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005829 [cytosol]
GO:0006693 [prostaglandin metabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007565 [female pregnancy]
GO:0007567 [parturition]
GO:0008152 [metabolic process]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016491 [oxidoreductase activity]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0019372 [lipoxygenase pathway]
GO:0030728 [ovulation]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070403 [NAD+ binding]
GO:0070493 [thrombin receptor signaling pathway]
GO:0097070 [ductus arteriosus closure]
GO:2001300 [lipoxin metabolic process]
Show all
 145 aa
15.7 kDa 		No 0
HPGD-202
ENSP00000443644
ENST00000542498
P15428 [Direct mapping]
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005829 [cytosol]
GO:0006693 [prostaglandin metabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007565 [female pregnancy]
GO:0007567 [parturition]
GO:0008152 [metabolic process]
GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity]
GO:0016491 [oxidoreductase activity]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0019372 [lipoxygenase pathway]
GO:0030728 [ovulation]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070403 [NAD+ binding]
GO:0070493 [thrombin receptor signaling pathway]
GO:0097070 [ductus arteriosus closure]
GO:2001300 [lipoxin metabolic process]
Show all
 143 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.