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MOCS2

CANCER ATLAS

Gene description

 Molybdenum cofactor synthesis 2

Protein class

 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037679
HPA037680

GENE INFORMATION

Gene name

 MOCS2 (HGNC Symbol)

Synonyms

 MOCO1

Description

 Molybdenum cofactor synthesis 2 (HGNC Symbol)

Entrez gene summary

 Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q11.2

Chromosome location (bp)

 53095679 - 53110063

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164172 (version 83.38)

Entrez gene

 4338

UniProt

 O96007 (UniProt - Evidence at protein level), O96033 (UniProt - Evidence at protein level)

neXtProt

 NX_O96007, NX_O96033

Antibodypedia

 MOCS2 antibodies

PROTEIN BROWSER
MOCS2-001
MOCS2-002
MOCS2-004
MOCS2-006
MOCS2-007
MOCS2-008
MOCS2-009
MOCS2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MOCS2-001
ENSP00000380157
ENST00000396954
O96007 [Direct mapping]
Molybdopterin synthase catalytic subunit
A0A024QZS1 [Target identity:100%; Query identity:100%]
Molybdopterin synthase catalytic subunit
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0030366 [molybdopterin synthase activity]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
Show all
 188 aa
20.9 kDa 		No 0
MOCS2-002
ENSP00000411022
ENST00000450852
O96033 [Direct mapping]
Molybdopterin synthase sulfur carrier subunit
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0030366 [molybdopterin synthase activity]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 88 aa
9.8 kDa 		No 0
MOCS2-004
ENSP00000355160
ENST00000361377
O96033 [Direct mapping]
Molybdopterin synthase sulfur carrier subunit
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0030366 [molybdopterin synthase activity]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 88 aa
9.8 kDa 		No 0
MOCS2-006
ENSP00000426274
ENST00000508922
O96033 [Direct mapping]
Molybdopterin synthase sulfur carrier subunit
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0030366 [molybdopterin synthase activity]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 88 aa
9.8 kDa 		No 0
MOCS2-007
ENSP00000424267
ENST00000510818
O96033 [Direct mapping]
Molybdopterin synthase sulfur carrier subunit
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0030366 [molybdopterin synthase activity]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 88 aa
9.8 kDa 		No 0
MOCS2-008
ENSP00000435326
ENST00000527216
E9PKT9 [Direct mapping]
Molybdopterin synthase sulfur carrier subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005829 [cytosol]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0030366 [molybdopterin synthase activity]
Show all
 83 aa
9.2 kDa 		No 0
MOCS2-009
ENSP00000462870
ENST00000582677
O96033 [Direct mapping]
Molybdopterin synthase sulfur carrier subunit
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0030366 [molybdopterin synthase activity]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 88 aa
9.8 kDa 		No 0
MOCS2-010
ENSP00000464663
ENST00000584946
O96033 [Direct mapping]
Molybdopterin synthase sulfur carrier subunit
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0019008 [molybdopterin synthase complex]
GO:0030366 [molybdopterin synthase activity]
GO:0032324 [molybdopterin cofactor biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 88 aa
9.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.