Cell atlas - MOCS2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MOCS2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MOCS2
Gene description	Molybdenum cofactor synthesis 2
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (uncertain), Cytosol (supported)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA037680
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & cytosol.

Main location

Nucleus (uncertain), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA037680	A-431	Nuclear speckles
	HPA037680	A-431	Cytosol
	HPA037680	U-2 OS	Nucleus
	HPA037680	U-2 OS	Cytosol
	HPA037680	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MOCS2 (HGNC Symbol)
Synonyms	MOCO1
Description	Molybdenum cofactor synthesis 2 (HGNC Symbol)
Entrez gene summary	Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q11.2
Chromosome location (bp)	53095679 - 53110063
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164172 (version 83.38)
Entrez gene	4338
UniProt	O96007 (UniProt - Evidence at protein level), O96033 (UniProt - Evidence at protein level)
neXtProt	NX_O96007, NX_O96033
Antibodypedia	MOCS2 antibodies

PROTEIN BROWSER

MOCS2-001	MOCS2-002	MOCS2-004	MOCS2-006	MOCS2-007	MOCS2-008	MOCS2-009	MOCS2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MOCS2-001 ENSP00000380157 ENST00000396954	O96007 [Direct mapping] Molybdopterin synthase catalytic subunit A0A024QZS1 [Target identity:100%; Query identity:100%] Molybdopterin synthase catalytic subunit Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006777 [Mo-molybdopterin cofactor biosynthetic process] GO:0019008 [molybdopterin synthase complex] GO:0030366 [molybdopterin synthase activity] GO:0032324 [molybdopterin cofactor biosynthetic process] GO:0044281 [small molecule metabolic process] Show all	188 aa 20.9 kDa	No	0
MOCS2-002 ENSP00000411022 ENST00000450852	O96033 [Direct mapping] Molybdopterin synthase sulfur carrier subunit Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006777 [Mo-molybdopterin cofactor biosynthetic process] GO:0019008 [molybdopterin synthase complex] GO:0030366 [molybdopterin synthase activity] GO:0032324 [molybdopterin cofactor biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	88 aa 9.8 kDa	No	0
MOCS2-004 ENSP00000355160 ENST00000361377	O96033 [Direct mapping] Molybdopterin synthase sulfur carrier subunit Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006777 [Mo-molybdopterin cofactor biosynthetic process] GO:0019008 [molybdopterin synthase complex] GO:0030366 [molybdopterin synthase activity] GO:0032324 [molybdopterin cofactor biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	88 aa 9.8 kDa	No	0
MOCS2-006 ENSP00000426274 ENST00000508922	O96033 [Direct mapping] Molybdopterin synthase sulfur carrier subunit Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006777 [Mo-molybdopterin cofactor biosynthetic process] GO:0019008 [molybdopterin synthase complex] GO:0030366 [molybdopterin synthase activity] GO:0032324 [molybdopterin cofactor biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	88 aa 9.8 kDa	No	0
MOCS2-007 ENSP00000424267 ENST00000510818	O96033 [Direct mapping] Molybdopterin synthase sulfur carrier subunit Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006777 [Mo-molybdopterin cofactor biosynthetic process] GO:0019008 [molybdopterin synthase complex] GO:0030366 [molybdopterin synthase activity] GO:0032324 [molybdopterin cofactor biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	88 aa 9.8 kDa	No	0
MOCS2-008 ENSP00000435326 ENST00000527216	E9PKT9 [Direct mapping] Molybdopterin synthase sulfur carrier subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005829 [cytosol] GO:0006777 [Mo-molybdopterin cofactor biosynthetic process] GO:0019008 [molybdopterin synthase complex] GO:0030366 [molybdopterin synthase activity] Show all	83 aa 9.2 kDa	No	0
MOCS2-009 ENSP00000462870 ENST00000582677	O96033 [Direct mapping] Molybdopterin synthase sulfur carrier subunit Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006777 [Mo-molybdopterin cofactor biosynthetic process] GO:0019008 [molybdopterin synthase complex] GO:0030366 [molybdopterin synthase activity] GO:0032324 [molybdopterin cofactor biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	88 aa 9.8 kDa	No	0
MOCS2-010 ENSP00000464663 ENST00000584946	O96033 [Direct mapping] Molybdopterin synthase sulfur carrier subunit Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006777 [Mo-molybdopterin cofactor biosynthetic process] GO:0019008 [molybdopterin synthase complex] GO:0030366 [molybdopterin synthase activity] GO:0032324 [molybdopterin cofactor biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	88 aa 9.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.