Expression of PRDM9 in cancer - Summary

CANCER ATLAS

Gene description

PR domain containing 9

Protein class

Enzymes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA059555

GENE INFORMATION
Gene name	PRDM9 (HGNC Symbol)
Synonyms	MSBP3, PFM6, ZNF899
Description	PR domain containing 9 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
Chromosome	5
Cytoband	p14.2
Chromosome location (bp)	23443586 - 23528597
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164256 (version 83.38)
Entrez gene	56979
UniProt	Q9NQV7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQV7
Antibodypedia	PRDM9 antibodies

PROTEIN BROWSER

PRDM9-001	PRDM9-003	PRDM9-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRDM9-001 ENSP00000296682 ENST00000296682	Q9NQV7 [Direct mapping] Histone-lysine N-methyltransferase PRDM9 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006311 [meiotic gene conversion] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007283 [spermatogenesis] GO:0010844 [recombination hotspot binding] GO:0010845 [positive regulation of reciprocal meiotic recombination] GO:0016571 [histone methylation] GO:0034968 [histone lysine methylation] GO:0042800 [histone methyltransferase activity (H3-K4 specific)] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051568 [histone H3-K4 methylation] GO:0060903 [positive regulation of meiosis I] Show all	894 aa 103.4 kDa	No	0
PRDM9-003 ENSP00000425471 ENST00000502755	D6RD68 [Direct mapping] Histone-lysine N-methyltransferase PRDM9 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	100 aa 12 kDa	No	0
PRDM9-004 ENSP00000489227 ENST00000635252		Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	411 aa 47.1 kDa	No	0