Tissue expression of PRDM9 - Summary - The Human Protein Atlas

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PRDM9

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PRDM9
Gene description	PR domain containing 9
Protein class	Enzymes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (testis, epididymis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA059555
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (testis, epididymis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	PRDM9 (HGNC Symbol)
Synonyms	MSBP3, PFM6, ZNF899
Description	PR domain containing 9 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
Chromosome	5
Cytoband	p14.2
Chromosome location (bp)	23443586 - 23528597
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164256 (version 83.38)
Entrez gene	56979
UniProt	Q9NQV7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQV7
Antibodypedia	PRDM9 antibodies

PROTEIN BROWSER

PRDM9-001	PRDM9-003	PRDM9-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRDM9-001 ENSP00000296682 ENST00000296682	Q9NQV7 [Direct mapping] Histone-lysine N-methyltransferase PRDM9 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006311 [meiotic gene conversion] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007283 [spermatogenesis] GO:0010844 [recombination hotspot binding] GO:0010845 [positive regulation of reciprocal meiotic recombination] GO:0016571 [histone methylation] GO:0034968 [histone lysine methylation] GO:0042800 [histone methyltransferase activity (H3-K4 specific)] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051568 [histone H3-K4 methylation] GO:0060903 [positive regulation of meiosis I] Show all	894 aa 103.4 kDa	No	0
PRDM9-003 ENSP00000425471 ENST00000502755	D6RD68 [Direct mapping] Histone-lysine N-methyltransferase PRDM9 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	100 aa 12 kDa	No	0
PRDM9-004 ENSP00000489227 ENST00000635252		Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	411 aa 47.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.