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PRDM9

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GENERAL INFORMATION

Gene name

 PRDM9

Gene description

 PR domain containing 9

Protein class

 Enzymes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (U-266/70)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (U-266/70)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 PRDM9 (HGNC Symbol)

Synonyms

 MSBP3, PFM6, ZNF899

Description

 PR domain containing 9 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]

Chromosome

 5

Cytoband

 p14.2

Chromosome location (bp)

 23443586 - 23528597

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164256 (version 83.38)

Entrez gene

 56979

UniProt

 Q9NQV7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQV7

Antibodypedia

 PRDM9 antibodies

PROTEIN BROWSER
PRDM9-001
PRDM9-003
PRDM9-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRDM9-001
ENSP00000296682
ENST00000296682
Q9NQV7 [Direct mapping]
Histone-lysine N-methyltransferase PRDM9
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006311 [meiotic gene conversion]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007283 [spermatogenesis]
GO:0010844 [recombination hotspot binding]
GO:0010845 [positive regulation of reciprocal meiotic recombination]
GO:0016571 [histone methylation]
GO:0034968 [histone lysine methylation]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051568 [histone H3-K4 methylation]
GO:0060903 [positive regulation of meiosis I]
Show all
 894 aa
103.4 kDa 		No 0
PRDM9-003
ENSP00000425471
ENST00000502755
D6RD68 [Direct mapping]
Histone-lysine N-methyltransferase PRDM9
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 100 aa
12 kDa 		No 0
PRDM9-004
ENSP00000489227
ENST00000635252
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 411 aa
47.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.