Fields »
ABOUT
HELP
BLOG
PTTG1

GENERAL INFORMATION

Gene name

 PTTG1

Gene description

 Pituitary tumor-transforming 1

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Group enriched (testis, esophagus, thyroid gland)
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in proliferating cells. Most abundant in testis and germinal center cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA008890 , HPA045034 , CAB008373
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, esophagus, thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 PTTG1 (HGNC Symbol)

Synonyms

 EAP1, HPTTG, PTTG, securin, TUTR1

Description

 Pituitary tumor-transforming 1 (HGNC Symbol)

Entrez gene summary

 The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

 5

Cytoband

 q33.3

Chromosome location (bp)

 160421822 - 160428744

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164611 (version 83.38)

Entrez gene

 9232

UniProt

 O95997 (UniProt - Evidence at protein level)

neXtProt

 NX_O95997

Antibodypedia

 PTTG1 antibodies

PROTEIN BROWSER
PTTG1-001
PTTG1-002
PTTG1-004
PTTG1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTTG1-001
ENSP00000377536
ENST00000393964
O95997 [Direct mapping]
Securin
Q6IAL9 [Target identity:100%; Query identity:100%]
PTTG1 protein; Pituitary tumor-transforming 1; Pituitary tumor-transforming 1, isoform CRA_a; cDNA, FLJ92498, Homo sapiens pituitary tumor-transforming 1 (PTTG1), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000278 [mitotic cell cycle]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007067 [mitotic nuclear division]
GO:0007283 [spermatogenesis]
GO:0010466 [negative regulation of peptidase activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0017124 [SH3 domain binding]
GO:0030414 [peptidase inhibitor activity]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0045143 [homologous chromosome segregation]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:2000816 [negative regulation of mitotic sister chromatid separation]
Show all
 202 aa
22 kDa 		No 0
PTTG1-002
ENSP00000344936
ENST00000352433
O95997 [Direct mapping]
Securin
Q6IAL9 [Target identity:100%; Query identity:100%]
PTTG1 protein; Pituitary tumor-transforming 1; Pituitary tumor-transforming 1, isoform CRA_a; cDNA, FLJ92498, Homo sapiens pituitary tumor-transforming 1 (PTTG1), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007067 [mitotic nuclear division]
GO:0007283 [spermatogenesis]
GO:0010466 [negative regulation of peptidase activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0017124 [SH3 domain binding]
GO:0030414 [peptidase inhibitor activity]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0045143 [homologous chromosome segregation]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:2000816 [negative regulation of mitotic sister chromatid separation]
Show all
 202 aa
22 kDa 		No 0
PTTG1-004
ENSP00000431068
ENST00000517480
E5RJR4 [Direct mapping]
Securin
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0051276 [chromosome organization]
Show all
 121 aa
12.9 kDa 		No 0
PTTG1-006
ENSP00000430642
ENST00000520452
O95997 [Direct mapping]
Securin
Q6IAL9 [Target identity:100%; Query identity:100%]
PTTG1 protein; Pituitary tumor-transforming 1; Pituitary tumor-transforming 1, isoform CRA_a; cDNA, FLJ92498, Homo sapiens pituitary tumor-transforming 1 (PTTG1), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000278 [mitotic cell cycle]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007067 [mitotic nuclear division]
GO:0007283 [spermatogenesis]
GO:0010466 [negative regulation of peptidase activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0017124 [SH3 domain binding]
GO:0030414 [peptidase inhibitor activity]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0045143 [homologous chromosome segregation]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:2000816 [negative regulation of mitotic sister chromatid separation]
Show all
 202 aa
22 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.