Cell atlas - SUN1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SUN1
Gene description	Sad1 and UNC84 domain containing 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	17
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA008346 , HPA008461
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane.

Main location

Nuclear membrane (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA008346	A-431	Nuclear membrane
HPA008346	U-2 OS	Nuclear membrane
HPA008346	U-251 MG	Nuclear membrane
HPA008461	A-431	Nuclear membrane
HPA008461	A-431	Vesicles
HPA008461	U-2 OS	Nuclear membrane
HPA008461	U-2 OS	Vesicles
HPA008461	U-251 MG	Nuclear membrane
HPA008461	U-251 MG	Vesicles

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

HPA008346

siRNA validation

Validated: Significant downregulation > 25% by one siRNA and > 10% by the other.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

50%

77%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Sample	Cell line
HPA008346	siRNA 2	U-2 OS
HPA008346	scrambled	U-2 OS
HPA008346	siRNA 1	U-2 OS

GENE INFORMATION
Gene name	SUN1 (HGNC Symbol)
Synonyms	FLJ12407, KIAA0810, UNC84A
Description	Sad1 and UNC84 domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2010]
Chromosome	7
Cytoband	p22.3
Chromosome location (bp)	816615 - 896435
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164828 (version 83.38)
Entrez gene	23353
UniProt	O94901 (UniProt - Evidence at protein level)
neXtProt	NX_O94901
Antibodypedia	SUN1 antibodies

PROTEIN BROWSER

SUN1-001	SUN1-002	SUN1-005	SUN1-007	SUN1-008	SUN1-012	SUN1-013	SUN1-015	SUN1-016	SUN1-017	SUN1-018	SUN1-019	SUN1-024	SUN1-027	SUN1-201	SUN1-202	SUN1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SUN1-001 ENSP00000384116 ENST00000405266	E9PHI4 [Direct mapping] SUN domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	822 aa 91.1 kDa	No	3
SUN1-002 ENSP00000374225 ENST00000389574	O94901 [Direct mapping] SUN domain-containing protein 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0006998 [nuclear envelope organization] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0043231 [intracellular membrane-bounded organelle] GO:0043495 [protein anchor] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	702 aa 77.9 kDa	No	2
SUN1-005 ENSP00000384015 ENST00000401592	O94901 [Direct mapping] SUN domain-containing protein 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0002080 [acrosomal membrane] GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005639 [integral component of nuclear inner membrane] GO:0005737 [cytoplasm] GO:0006998 [nuclear envelope organization] GO:0007129 [synapsis] GO:0009612 [response to mechanical stimulus] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0043231 [intracellular membrane-bounded organelle] GO:0043495 [protein anchor] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	785 aa 87.1 kDa	No	2
SUN1-007 ENSP00000383947 ENST00000403868	O94901 [Direct mapping] SUN domain-containing protein 1 Show all	Transporters Transporter channels and pores Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0006998 [nuclear envelope organization] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0043231 [intracellular membrane-bounded organelle] GO:0043495 [protein anchor] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	257 aa 28.1 kDa	No	0
SUN1-008 ENSP00000409909 ENST00000429178	H0Y742 [Direct mapping] SUN domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	710 aa 79.6 kDa	No	2
SUN1-012 ENSP00000406653 ENST00000433212	H0Y6N5 [Direct mapping] SUN domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	634 aa 70.9 kDa	No	3
SUN1-013 ENSP00000388430 ENST00000435699	C9JK55 [Direct mapping] SUN domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		174 aa 18.8 kDa	No	0
SUN1-015 ENSP00000399549 ENST00000440380	C9JR15 [Direct mapping] SUN domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 9.5 kDa	No	0
SUN1-016 ENSP00000413188 ENST00000439679	C9K051 [Direct mapping] SUN domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		135 aa 14.6 kDa	No	0
SUN1-017 ENSP00000394597 ENST00000424128	C9JR15 [Direct mapping] SUN domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 9.5 kDa	No	0
SUN1-018 ENSP00000404965 ENST00000457598	C9JJU6 [Direct mapping] SUN domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 12.9 kDa	No	0
SUN1-019 ENSP00000394381 ENST00000421580	C9JS54 [Direct mapping] SUN domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 12.4 kDa	No	0
SUN1-024 ENSP00000392595 ENST00000450881	H7C019 [Direct mapping] SUN domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	171 aa 19 kDa	No	1
SUN1-027 ENSP00000414279 ENST00000419312	H7C3X3 [Direct mapping] SUN domain-containing protein 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		158 aa 16.8 kDa	No	0
SUN1-201 ENSP00000392309 ENST00000425407	O94901 [Direct mapping] SUN domain-containing protein 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0006998 [nuclear envelope organization] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0043231 [intracellular membrane-bounded organelle] GO:0043495 [protein anchor] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	702 aa 77.9 kDa	No	2
SUN1-202 ENSP00000413439 ENST00000452783	O94901 [Direct mapping] SUN domain-containing protein 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0006998 [nuclear envelope organization] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0043231 [intracellular membrane-bounded organelle] GO:0043495 [protein anchor] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	682 aa 76.4 kDa	No	2
SUN1-203 ENSP00000395952 ENST00000457378	O94901 [Direct mapping] SUN domain-containing protein 1 Show all	Transporters Transporter channels and pores Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0006998 [nuclear envelope organization] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0043231 [intracellular membrane-bounded organelle] GO:0043495 [protein anchor] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	278 aa 30.4 kDa	No	0