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FBP1

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GENERAL INFORMATION

Gene name

 FBP1

Gene description

 Fructose-1,6-bisphosphatase 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Cell line enhanced (MCF7, RT4, U-698, HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA005857
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MCF7, RT4, U-698, HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA005857 MCF7 Mitochondria
HPA005857 U-2 OS Mitochondria
HPA005857 U-251 MG No staining    

GENE INFORMATION

Gene name

 FBP1 (HGNC Symbol)

Synonyms

 FBP

Description

 Fructose-1,6-bisphosphatase 1 (HGNC Symbol)

Entrez gene summary

 Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q22.32

Chromosome location (bp)

 94603133 - 94640249

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165140 (version 83.38)

Entrez gene

 2203

UniProt

 P09467 (UniProt - Evidence at protein level)

neXtProt

 NX_P09467

Antibodypedia

 FBP1 antibodies

PROTEIN BROWSER
FBP1-001
FBP1-002
FBP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBP1-001
ENSP00000364475
ENST00000375326
P09467 [Direct mapping]
Fructose-1,6-bisphosphatase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006111 [regulation of gluconeogenesis]
GO:0016208 [AMP binding]
GO:0016311 [dephosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0035690 [cellular response to drug]
GO:0042132 [fructose 1,6-bisphosphate 1-phosphatase activity]
GO:0042578 [phosphoric ester hydrolase activity]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0045820 [negative regulation of glycolytic process]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0048029 [monosaccharide binding]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:0071286 [cellular response to magnesium ion]
Show all
 338 aa
36.8 kDa 		No 0
FBP1-002
ENSP00000411619
ENST00000414122
Q5VZC3 [Direct mapping]
Fructose-1,6-bisphosphatase 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005975 [carbohydrate metabolic process]
GO:0016311 [dephosphorylation]
GO:0042132 [fructose 1,6-bisphosphate 1-phosphatase activity]
GO:0042578 [phosphoric ester hydrolase activity]
Show all
 151 aa
16.7 kDa 		No 0
FBP1-201
ENSP00000408025
ENST00000415431
P09467 [Direct mapping]
Fructose-1,6-bisphosphatase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006111 [regulation of gluconeogenesis]
GO:0016208 [AMP binding]
GO:0016311 [dephosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0035690 [cellular response to drug]
GO:0042132 [fructose 1,6-bisphosphate 1-phosphatase activity]
GO:0042578 [phosphoric ester hydrolase activity]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0045820 [negative regulation of glycolytic process]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0048029 [monosaccharide binding]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:0071286 [cellular response to magnesium ion]
Show all
 338 aa
36.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.