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Group enriched (liver, small intestine, lung, colon)
Protein evidence
Evidence at protein level
Protein expression
Cytoplasmic expression in several tissues, most abundant in liver.
DATA RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
RNA tissue category: Group enriched (liver, small intestine, lung, colon)
GENE INFORMATION
Gene name
FBP1 (HGNC Symbol)
Synonyms
FBP
Description
Fructose-1,6-bisphosphatase 1 (HGNC Symbol)
Entrez gene summary
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006000 [fructose metabolic process] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006111 [regulation of gluconeogenesis] GO:0016208 [AMP binding] GO:0016311 [dephosphorylation] GO:0030308 [negative regulation of cell growth] GO:0035690 [cellular response to drug] GO:0042132 [fructose 1,6-bisphosphate 1-phosphatase activity] GO:0042578 [phosphoric ester hydrolase activity] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] GO:0045820 [negative regulation of glycolytic process] GO:0046580 [negative regulation of Ras protein signal transduction] GO:0046872 [metal ion binding] GO:0048029 [monosaccharide binding] GO:0051289 [protein homotetramerization] GO:0070062 [extracellular exosome] GO:0071286 [cellular response to magnesium ion]
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006000 [fructose metabolic process] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006111 [regulation of gluconeogenesis] GO:0016208 [AMP binding] GO:0016311 [dephosphorylation] GO:0030308 [negative regulation of cell growth] GO:0035690 [cellular response to drug] GO:0042132 [fructose 1,6-bisphosphate 1-phosphatase activity] GO:0042578 [phosphoric ester hydrolase activity] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] GO:0045820 [negative regulation of glycolytic process] GO:0046580 [negative regulation of Ras protein signal transduction] GO:0046872 [metal ion binding] GO:0048029 [monosaccharide binding] GO:0051289 [protein homotetramerization] GO:0070062 [extracellular exosome] GO:0071286 [cellular response to magnesium ion]
