Fields »
ABOUT
HELP
BLOG
ANKRD2

CANCER ATLAS

Gene description

 Ankyrin repeat domain 2 (stretch responsive muscle)

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA040842
HPA040884

GENE INFORMATION

Gene name

 ANKRD2 (HGNC Symbol)

Synonyms

 ARPP

Description

 Ankyrin repeat domain 2 (stretch responsive muscle) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Chromosome

 10

Cytoband

 q24.2

Chromosome location (bp)

 97572499 - 97583884

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165887 (version 83.38)

Entrez gene

 26287

UniProt

 Q9GZV1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZV1

Antibodypedia

 ANKRD2 antibodies

PROTEIN BROWSER
ANKRD2-001
ANKRD2-002
ANKRD2-201
ANKRD2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANKRD2-001
ENSP00000359689
ENST00000370655
A0A0A0MRN9 [Direct mapping]
Ankyrin repeat domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
Show all
 333 aa
37.1 kDa 		No 0
ANKRD2-002
ENSP00000403114
ENST00000455090
Q5T457 [Direct mapping]
Ankyrin repeat domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 300 aa
33.5 kDa 		No 0
ANKRD2-201
ENSP00000298808
ENST00000298808
Q9GZV1 [Direct mapping]
Ankyrin repeat domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000791 [euchromatin]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007517 [muscle organ development]
GO:0008307 [structural constituent of muscle]
GO:0016605 [PML body]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
GO:0031674 [I band]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043422 [protein kinase B binding]
GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0061629 [RNA polymerase II sequence-specific DNA binding transcription factor binding]
Show all
 327 aa
36.2 kDa 		No 0
ANKRD2-202
ENSP00000306163
ENST00000307518
Q9GZV1 [Direct mapping]
Ankyrin repeat domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000791 [euchromatin]
GO:0001817 [regulation of cytokine production]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007517 [muscle organ development]
GO:0008307 [structural constituent of muscle]
GO:0010832 [negative regulation of myotube differentiation]
GO:0016605 [PML body]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
GO:0031674 [I band]
GO:0035914 [skeletal muscle cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043422 [protein kinase B binding]
GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0061629 [RNA polymerase II sequence-specific DNA binding transcription factor binding]
GO:1902253 [regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
GO:2000291 [regulation of myoblast proliferation]
Show all
 360 aa
39.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.