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ANKRD2

GENERAL INFORMATION

Gene name

 ANKRD2

Gene description

 Ankyrin repeat domain 2 (stretch responsive muscle)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (skeletal muscle, heart muscle)
GTEx:Group enriched (skeletal muscle, heart muscle)
FANTOM5:Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in myocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA040842 , HPA040884
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION

Gene name

 ANKRD2 (HGNC Symbol)

Synonyms

 ARPP

Description

 Ankyrin repeat domain 2 (stretch responsive muscle) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Chromosome

 10

Cytoband

 q24.2

Chromosome location (bp)

 97572499 - 97583884

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165887 (version 83.38)

Entrez gene

 26287

UniProt

 Q9GZV1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZV1

Antibodypedia

 ANKRD2 antibodies

PROTEIN BROWSER
ANKRD2-001
ANKRD2-002
ANKRD2-201
ANKRD2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANKRD2-001
ENSP00000359689
ENST00000370655
A0A0A0MRN9 [Direct mapping]
Ankyrin repeat domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
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 333 aa
37.1 kDa 		No 0
ANKRD2-002
ENSP00000403114
ENST00000455090
Q5T457 [Direct mapping]
Ankyrin repeat domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
GO:0043231 [intracellular membrane-bounded organelle]
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 300 aa
33.5 kDa 		No 0
ANKRD2-201
ENSP00000298808
ENST00000298808
Q9GZV1 [Direct mapping]
Ankyrin repeat domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000791 [euchromatin]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007517 [muscle organ development]
GO:0008307 [structural constituent of muscle]
GO:0016605 [PML body]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
GO:0031674 [I band]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043422 [protein kinase B binding]
GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0061629 [RNA polymerase II sequence-specific DNA binding transcription factor binding]
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 327 aa
36.2 kDa 		No 0
ANKRD2-202
ENSP00000306163
ENST00000307518
Q9GZV1 [Direct mapping]
Ankyrin repeat domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000791 [euchromatin]
GO:0001817 [regulation of cytokine production]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007517 [muscle organ development]
GO:0008307 [structural constituent of muscle]
GO:0010832 [negative regulation of myotube differentiation]
GO:0016605 [PML body]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
GO:0031674 [I band]
GO:0035914 [skeletal muscle cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043422 [protein kinase B binding]
GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0061629 [RNA polymerase II sequence-specific DNA binding transcription factor binding]
GO:1902253 [regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
GO:2000291 [regulation of myoblast proliferation]
Show all
 360 aa
39.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.