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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CACNB2
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLASi

The cancer tissue page shows antibody staining in 20 different cancers. The assay and annotation is described here.

This page starts with information about the protein evidence and, when applicable, also protein class. Below the summary, a selection of four standard cancer tissue samples is displayed as representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional 5th image can be added as a complement.

For histological reference, visit the histological dictionary.

Gene description

Calcium channel, voltage-dependent, beta 2 subunit

Protein class

Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi

The cancer tissue summary page shows antibody staining in 20 different cancers. The assay and annotation is described here.

For each cancer, the fraction of samples with antibody staining/protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The tooltip function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

At the bottom of the page, a summary of the overall protein expression pattern across the analyzed cancer tissues as well as information about literature conformity are presented.

HPA035325
HPA035326

Tissue

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Tissue

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Cancer tissues were negative.

Tissue

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Tissue

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Hepatocellular carcinomas and a few cases of lymphoma showed moderate cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

CACNB2 (HGNC Symbol)

Synonyms

CACNLB2, MYSB

Description

Calcium channel, voltage-dependent, beta 2 subunit (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]

Chromosome

10

Cytoband

Chromosome location (bp)

18140677 - 18541869

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165995 (version 83.38)

Entrez gene

783

UniProt

Q08289 (UniProt - Evidence at protein level)

neXtProt

NX_Q08289

Antibodypedia

CACNB2 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

«
CACNB2-001
CACNB2-002
CACNB2-003
CACNB2-004
CACNB2-005
CACNB2-007
CACNB2-008
CACNB2-009
CACNB2-010
CACNB2-201
CACNB2-202
CACNB2-203
CACNB2-204
»

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CACNB2-001
ENSP00000320025
ENST00000324631
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005246 [calcium channel regulator activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0007601 [visual perception]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0042383 [sarcolemma]
GO:0051219 [phosphoprotein binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
660 aa
73.6 kDa
No 0
CACNB2-002
ENSP00000282343
ENST00000282343
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
632 aa
70.8 kDa
No 0
CACNB2-003
ENSP00000379821
ENST00000396576
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
605 aa
68.1 kDa
No 0
CACNB2-004
ENSP00000366532
ENST00000377315
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Q5VVH1 [Target identity:100%; Query identity:100%]
cDNA FLJ50648, highly similar to Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
612 aa
68.8 kDa
No 0
CACNB2-005
ENSP00000366536
ENST00000377319
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
567 aa
64 kDa
No 0
CACNB2-007
ENSP00000366546
ENST00000377329
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
606 aa
68.2 kDa
No 0
CACNB2-008
ENSP00000344474
ENST00000352115
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
636 aa
71.1 kDa
No 0
CACNB2-009
ENSP00000366545
ENST00000377328
A6PVM6 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
410 aa
45.8 kDa
No 0
CACNB2-010
ENSP00000366548
ENST00000377331
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
608 aa
68.3 kDa
No 0
CACNB2-201
ENSP00000480563
ENST00000612134
Q6TME0 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2; Voltage-gated calcium channel beta 2 subunit splice variant CavB2dN4
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
176 aa
19.5 kDa
No 0
CACNB2-202
ENSP00000478676
ENST00000612743
A0A087WUH4 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
164 aa
19.5 kDa
No 0
CACNB2-203
ENSP00000480260
ENST00000615785
A0A087WWJ0 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
355 aa
40.4 kDa
No 0
CACNB2-204
ENSP00000479756
ENST00000617363
A0A087WVX5 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
581 aa
65.6 kDa
No 0

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