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CACNB2

CANCER ATLAS

Gene description

 Calcium channel, voltage-dependent, beta 2 subunit

Protein class

 Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035325
HPA035326

GENE INFORMATION

Gene name

 CACNB2 (HGNC Symbol)

Synonyms

 CACNLB2, MYSB

Description

 Calcium channel, voltage-dependent, beta 2 subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]

Chromosome

 10

Cytoband

Chromosome location (bp)

 18140677 - 18541869

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165995 (version 83.38)

Entrez gene

 783

UniProt

 Q08289 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08289

Antibodypedia

 CACNB2 antibodies

PROTEIN BROWSER
«
CACNB2-001
CACNB2-002
CACNB2-003
CACNB2-004
CACNB2-005
CACNB2-007
CACNB2-008
CACNB2-009
CACNB2-010
CACNB2-201
CACNB2-202
CACNB2-203
CACNB2-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CACNB2-001
ENSP00000320025
ENST00000324631
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005246 [calcium channel regulator activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0007601 [visual perception]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0042383 [sarcolemma]
GO:0051219 [phosphoprotein binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 660 aa
73.6 kDa 		No 0
CACNB2-002
ENSP00000282343
ENST00000282343
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 632 aa
70.8 kDa 		No 0
CACNB2-003
ENSP00000379821
ENST00000396576
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 605 aa
68.1 kDa 		No 0
CACNB2-004
ENSP00000366532
ENST00000377315
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Q5VVH1 [Target identity:100%; Query identity:100%]
cDNA FLJ50648, highly similar to Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 612 aa
68.8 kDa 		No 0
CACNB2-005
ENSP00000366536
ENST00000377319
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 567 aa
64 kDa 		No 0
CACNB2-007
ENSP00000366546
ENST00000377329
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 606 aa
68.2 kDa 		No 0
CACNB2-008
ENSP00000344474
ENST00000352115
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 636 aa
71.1 kDa 		No 0
CACNB2-009
ENSP00000366545
ENST00000377328
A6PVM6 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 410 aa
45.8 kDa 		No 0
CACNB2-010
ENSP00000366548
ENST00000377331
Q08289 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0042383 [sarcolemma]
GO:0051928 [positive regulation of calcium ion transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 608 aa
68.3 kDa 		No 0
CACNB2-201
ENSP00000480563
ENST00000612134
Q6TME0 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2; Voltage-gated calcium channel beta 2 subunit splice variant CavB2dN4
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 176 aa
19.5 kDa 		No 0
CACNB2-202
ENSP00000478676
ENST00000612743
A0A087WUH4 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 164 aa
19.5 kDa 		No 0
CACNB2-203
ENSP00000480260
ENST00000615785
A0A087WWJ0 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 355 aa
40.4 kDa 		No 0
CACNB2-204
ENSP00000479756
ENST00000617363
A0A087WVX5 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-2
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 581 aa
65.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.