Tissue expression of CACNB2 - Summary - The Human Protein Atlas

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CACNB2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CACNB2
Gene description	Calcium channel, voltage-dependent, beta 2 subunit
Protein class	Disease related genes FDA approved drug targets Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA035325 , HPA035326
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	CACNB2 (HGNC Symbol)
Synonyms	CACNLB2, MYSB
Description	Calcium channel, voltage-dependent, beta 2 subunit (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]
Chromosome	10
Cytoband
Chromosome location (bp)	18140677 - 18541869
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165995 (version 83.38)
Entrez gene	783
UniProt	Q08289 (UniProt - Evidence at protein level)
neXtProt	NX_Q08289
Antibodypedia	CACNB2 antibodies

PROTEIN BROWSER

CACNB2-001	CACNB2-002	CACNB2-003	CACNB2-004	CACNB2-005	CACNB2-007	CACNB2-008	CACNB2-009	CACNB2-010	CACNB2-201	CACNB2-202	CACNB2-203	CACNB2-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CACNB2-001 ENSP00000320025 ENST00000324631	Q08289 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005246 [calcium channel regulator activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007528 [neuromuscular junction development] GO:0007601 [visual perception] GO:0008331 [high voltage-gated calcium channel activity] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0042383 [sarcolemma] GO:0051219 [phosphoprotein binding] GO:0051928 [positive regulation of calcium ion transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	660 aa 73.6 kDa	No	0
CACNB2-002 ENSP00000282343 ENST00000282343	Q08289 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007528 [neuromuscular junction development] GO:0008331 [high voltage-gated calcium channel activity] GO:0042383 [sarcolemma] GO:0051928 [positive regulation of calcium ion transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	632 aa 70.8 kDa	No	0
CACNB2-003 ENSP00000379821 ENST00000396576	Q08289 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007528 [neuromuscular junction development] GO:0008331 [high voltage-gated calcium channel activity] GO:0042383 [sarcolemma] GO:0051928 [positive regulation of calcium ion transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	605 aa 68.1 kDa	No	0
CACNB2-004 ENSP00000366532 ENST00000377315	Q08289 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Q5VVH1 [Target identity:100%; Query identity:100%] cDNA FLJ50648, highly similar to Voltage-dependent L-type calcium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007528 [neuromuscular junction development] GO:0008331 [high voltage-gated calcium channel activity] GO:0042383 [sarcolemma] GO:0051928 [positive regulation of calcium ion transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	612 aa 68.8 kDa	No	0
CACNB2-005 ENSP00000366536 ENST00000377319	Q08289 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007528 [neuromuscular junction development] GO:0008331 [high voltage-gated calcium channel activity] GO:0042383 [sarcolemma] GO:0051928 [positive regulation of calcium ion transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	567 aa 64 kDa	No	0
CACNB2-007 ENSP00000366546 ENST00000377329	Q08289 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007528 [neuromuscular junction development] GO:0008331 [high voltage-gated calcium channel activity] GO:0042383 [sarcolemma] GO:0051928 [positive regulation of calcium ion transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	606 aa 68.2 kDa	No	0
CACNB2-008 ENSP00000344474 ENST00000352115	Q08289 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007528 [neuromuscular junction development] GO:0008331 [high voltage-gated calcium channel activity] GO:0042383 [sarcolemma] GO:0051928 [positive regulation of calcium ion transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	636 aa 71.1 kDa	No	0
CACNB2-009 ENSP00000366545 ENST00000377328	A6PVM6 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Show all	Predicted intracellular proteins Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005891 [voltage-gated calcium channel complex] GO:0007268 [synaptic transmission] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	410 aa 45.8 kDa	No	0
CACNB2-010 ENSP00000366548 ENST00000377331	Q08289 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006810 [transport] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007528 [neuromuscular junction development] GO:0008331 [high voltage-gated calcium channel activity] GO:0042383 [sarcolemma] GO:0051928 [positive regulation of calcium ion transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	608 aa 68.3 kDa	No	0
CACNB2-201 ENSP00000480563 ENST00000612134	Q6TME0 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2; Voltage-gated calcium channel beta 2 subunit splice variant CavB2dN4 Show all	Predicted intracellular proteins Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005891 [voltage-gated calcium channel complex] GO:0007268 [synaptic transmission] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	176 aa 19.5 kDa	No	0
CACNB2-202 ENSP00000478676 ENST00000612743	A0A087WUH4 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Show all	Predicted intracellular proteins Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0007268 [synaptic transmission] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	164 aa 19.5 kDa	No	0
CACNB2-203 ENSP00000480260 ENST00000615785	A0A087WWJ0 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Show all	Predicted intracellular proteins Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005891 [voltage-gated calcium channel complex] GO:0007268 [synaptic transmission] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	355 aa 40.4 kDa	No	0
CACNB2-204 ENSP00000479756 ENST00000617363	A0A087WVX5 [Direct mapping] Voltage-dependent L-type calcium channel subunit beta-2 Show all	Predicted intracellular proteins Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005891 [voltage-gated calcium channel complex] GO:0007268 [synaptic transmission] GO:0070588 [calcium ion transmembrane transport] GO:1901385 [regulation of voltage-gated calcium channel activity] Show all	581 aa 65.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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