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BAG5

CANCER ATLAS

Gene description

 BCL2-associated athanogene 5

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016429

GENE INFORMATION

Gene name

 BAG5

Synonyms

Description

 BCL2-associated athanogene 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q32.33

Chromosome location (bp)

 103556544 - 103562831

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166170 (version 83.38)

Entrez gene

 9529

UniProt

 Q9UL15 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UL15

Antibodypedia

 BAG5 antibodies

PROTEIN BROWSER
BAG5-001
BAG5-002
BAG5-003
BAG5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BAG5-001
ENSP00000391713
ENST00000445922
Q9UL15 [Direct mapping]
BAG family molecular chaperone regulator 5
A0A024R6M6 [Target identity:100%; Query identity:100%]
BCL2-associated athanogene 5; BCL2-associated athanogene 5, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0007030 [Golgi organization]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016234 [inclusion body]
GO:0019901 [protein kinase binding]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051087 [chaperone binding]
GO:0051438 [regulation of ubiquitin-protein transferase activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0061084 [negative regulation of protein refolding]
GO:0070997 [neuron death]
GO:0090083 [regulation of inclusion body assembly]
GO:1900034 [regulation of cellular response to heat]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Show all
 447 aa
51.2 kDa 		No 0
BAG5-002
ENSP00000338814
ENST00000337322
Q9UL15 [Direct mapping]
BAG family molecular chaperone regulator 5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0007030 [Golgi organization]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016234 [inclusion body]
GO:0019901 [protein kinase binding]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051087 [chaperone binding]
GO:0051438 [regulation of ubiquitin-protein transferase activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0061084 [negative regulation of protein refolding]
GO:0070997 [neuron death]
GO:0090083 [regulation of inclusion body assembly]
GO:1900034 [regulation of cellular response to heat]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Show all
 488 aa
56 kDa 		No 0
BAG5-003
ENSP00000450497
ENST00000557666
G3V274 [Direct mapping]
BAG family molecular chaperone regulator 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0051087 [chaperone binding]
Show all
 211 aa
24 kDa 		No 0
BAG5-201
ENSP00000299204
ENST00000299204
Q9UL15 [Direct mapping]
BAG family molecular chaperone regulator 5
A0A024R6M6 [Target identity:100%; Query identity:100%]
BCL2-associated athanogene 5; BCL2-associated athanogene 5, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0007030 [Golgi organization]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016234 [inclusion body]
GO:0019901 [protein kinase binding]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051087 [chaperone binding]
GO:0051438 [regulation of ubiquitin-protein transferase activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0061084 [negative regulation of protein refolding]
GO:0070997 [neuron death]
GO:0090083 [regulation of inclusion body assembly]
GO:1900034 [regulation of cellular response to heat]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Show all
 447 aa
51.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.