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BAG5

GENERAL INFORMATION

Gene name

 BAG5

Gene description

 BCL2-associated athanogene 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA016429
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 BAG5

Synonyms

Description

 BCL2-associated athanogene 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q32.33

Chromosome location (bp)

 103556544 - 103562831

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166170 (version 83.38)

Entrez gene

 9529

UniProt

 Q9UL15 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UL15

Antibodypedia

 BAG5 antibodies

PROTEIN BROWSER
BAG5-001
BAG5-002
BAG5-003
BAG5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BAG5-001
ENSP00000391713
ENST00000445922
Q9UL15 [Direct mapping]
BAG family molecular chaperone regulator 5
A0A024R6M6 [Target identity:100%; Query identity:100%]
BCL2-associated athanogene 5; BCL2-associated athanogene 5, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0007030 [Golgi organization]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016234 [inclusion body]
GO:0019901 [protein kinase binding]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051087 [chaperone binding]
GO:0051438 [regulation of ubiquitin-protein transferase activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0061084 [negative regulation of protein refolding]
GO:0070997 [neuron death]
GO:0090083 [regulation of inclusion body assembly]
GO:1900034 [regulation of cellular response to heat]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Show all
 447 aa
51.2 kDa 		No 0
BAG5-002
ENSP00000338814
ENST00000337322
Q9UL15 [Direct mapping]
BAG family molecular chaperone regulator 5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0007030 [Golgi organization]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016234 [inclusion body]
GO:0019901 [protein kinase binding]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051087 [chaperone binding]
GO:0051438 [regulation of ubiquitin-protein transferase activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0061084 [negative regulation of protein refolding]
GO:0070997 [neuron death]
GO:0090083 [regulation of inclusion body assembly]
GO:1900034 [regulation of cellular response to heat]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Show all
 488 aa
56 kDa 		No 0
BAG5-003
ENSP00000450497
ENST00000557666
G3V274 [Direct mapping]
BAG family molecular chaperone regulator 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0051087 [chaperone binding]
Show all
 211 aa
24 kDa 		No 0
BAG5-201
ENSP00000299204
ENST00000299204
Q9UL15 [Direct mapping]
BAG family molecular chaperone regulator 5
A0A024R6M6 [Target identity:100%; Query identity:100%]
BCL2-associated athanogene 5; BCL2-associated athanogene 5, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0007030 [Golgi organization]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016234 [inclusion body]
GO:0019901 [protein kinase binding]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051087 [chaperone binding]
GO:0051438 [regulation of ubiquitin-protein transferase activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0061084 [negative regulation of protein refolding]
GO:0070997 [neuron death]
GO:0090083 [regulation of inclusion body assembly]
GO:1900034 [regulation of cellular response to heat]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Show all
 447 aa
51.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.