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HSP90B1

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GENERAL INFORMATION

Gene name

 HSP90B1

Gene description

 Heat shock protein 90kDa beta (Grp94), member 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the endoplasmic reticulum.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Endoplasmic reticulum (validated)

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
HPA003901 , CAB005224 , HPA008424
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the endoplasmic reticulum.

Main location

 Endoplasmic reticulum (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA003901 A-431 Endoplasmic reticulum
HPA003901 U-2 OS Endoplasmic reticulum
HPA003901 U-251 MG Endoplasmic reticulum
CAB005224 A-431 Endoplasmic reticulum
CAB005224 U-2 OS Endoplasmic reticulum
CAB005224 U-251 MG Endoplasmic reticulum
HPA008424 A-431 Endoplasmic reticulum
HPA008424 U-2 OS Endoplasmic reticulum
HPA008424 U-251 MG Endoplasmic reticulum

GENE INFORMATION

Gene name

 HSP90B1 (HGNC Symbol)

Synonyms

 GP96, GRP94, TRA1

Description

 Heat shock protein 90kDa beta (Grp94), member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 103930107 - 103953645

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166598 (version 83.38)

Entrez gene

 7184

UniProt

 P14625 (UniProt - Evidence at protein level)

neXtProt

 NX_P14625

Antibodypedia

 HSP90B1 antibodies

PROTEIN BROWSER
HSP90B1-001
HSP90B1-006
HSP90B1-012
HSP90B1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSP90B1-001
ENSP00000299767
ENST00000299767
P14625 [Direct mapping]
Endoplasmin
V9HWP2 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 35; Epididymis secretory sperm binding protein Li 125m; Heat shock protein 90kDa beta (Grp94), member 1, isoform CRA_b
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0002224 [toll-like receptor signaling pathway]
GO:0003723 [RNA binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006457 [protein folding]
GO:0006898 [receptor-mediated endocytosis]
GO:0006950 [response to stress]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019903 [protein phosphatase binding]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030496 [midbody]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0031012 [extracellular matrix]
GO:0031247 [actin rod assembly]
GO:0034663 [endoplasmic reticulum chaperone complex]
GO:0034975 [protein folding in endoplasmic reticulum]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042470 [melanosome]
GO:0043066 [negative regulation of apoptotic process]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0046790 [virion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0051082 [unfolded protein binding]
GO:0051208 [sequestering of calcium ion]
GO:0070062 [extracellular exosome]
GO:0071318 [cellular response to ATP]
GO:0071682 [endocytic vesicle lumen]
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 803 aa
92.5 kDa 		Yes 0
HSP90B1-006
ENSP00000446748
ENST00000549334
F8W026 [Direct mapping]
Endoplasmin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]
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 49 aa
5.6 kDa 		No 0
HSP90B1-012
ENSP00000450215
ENST00000550595
H0YIV0 [Direct mapping]
Endoplasmin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]
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 147 aa
16.9 kDa 		No 0
HSP90B1-201
ENSP00000477660
ENST00000614327
Q96GW1 [Direct mapping]
Endoplasmin; HSP90B1 protein
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]
Show all
 315 aa
35.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.