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HSP90B1

GENERAL INFORMATION

Gene name

 HSP90B1

Gene description

 Heat shock protein 90kDa beta (Grp94), member 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Widely distributed cytoplasmic staining.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA003901 , HPA008424 , CAB005224
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HSP90B1 (HGNC Symbol)

Synonyms

 GP96, GRP94, TRA1

Description

 Heat shock protein 90kDa beta (Grp94), member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 103930107 - 103953645

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166598 (version 83.38)

Entrez gene

 7184

UniProt

 P14625 (UniProt - Evidence at protein level)

neXtProt

 NX_P14625

Antibodypedia

 HSP90B1 antibodies

PROTEIN BROWSER
HSP90B1-001
HSP90B1-006
HSP90B1-012
HSP90B1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSP90B1-001
ENSP00000299767
ENST00000299767
P14625 [Direct mapping]
Endoplasmin
V9HWP2 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 35; Epididymis secretory sperm binding protein Li 125m; Heat shock protein 90kDa beta (Grp94), member 1, isoform CRA_b
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0002224 [toll-like receptor signaling pathway]
GO:0003723 [RNA binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006457 [protein folding]
GO:0006898 [receptor-mediated endocytosis]
GO:0006950 [response to stress]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019903 [protein phosphatase binding]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030496 [midbody]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0031012 [extracellular matrix]
GO:0031247 [actin rod assembly]
GO:0034663 [endoplasmic reticulum chaperone complex]
GO:0034975 [protein folding in endoplasmic reticulum]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042470 [melanosome]
GO:0043066 [negative regulation of apoptotic process]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0046790 [virion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0051082 [unfolded protein binding]
GO:0051208 [sequestering of calcium ion]
GO:0070062 [extracellular exosome]
GO:0071318 [cellular response to ATP]
GO:0071682 [endocytic vesicle lumen]
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 803 aa
92.5 kDa 		Yes 0
HSP90B1-006
ENSP00000446748
ENST00000549334
F8W026 [Direct mapping]
Endoplasmin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]
Show all
 49 aa
5.6 kDa 		No 0
HSP90B1-012
ENSP00000450215
ENST00000550595
H0YIV0 [Direct mapping]
Endoplasmin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]
Show all
 147 aa
16.9 kDa 		No 0
HSP90B1-201
ENSP00000477660
ENST00000614327
Q96GW1 [Direct mapping]
Endoplasmin; HSP90B1 protein
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]
Show all
 315 aa
35.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.