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Most malignant cells showed weak to moderate cytoplasmic immunoreactivity frequently combined with nuclear positivity. A few malignant melanomas, colorectal and testicular cancers exhibited strong staining.
Most malignant cells showed weak to moderate cytoplasmic immunoreactivity. Several cases of hepatocellular carcinomas as well as a few pancreatic cancers displayed strong cytoplasmic positivity.
GENE INFORMATION
Gene name
ZNF598 (HGNC Symbol)
Synonyms
FLJ00086
Description
Zinc finger protein 598 (HGNC Symbol)
Entrez gene summary
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012]
