Tissue expression of ATXN2L - Summary - The Human Protein Atlas

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ATXN2L

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ATXN2L
Gene description	Ataxin 2-like
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, including a few cases of membrane expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA041506 , HPA043391
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Urinary bladder

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ATXN2L (HGNC Symbol)
Synonyms	A2D, A2lp
Description	Ataxin 2-like (HGNC Symbol)
Entrez gene summary	This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	28823035 - 28837237
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168488 (version 83.38)
Entrez gene	11273
UniProt	Q8WWM7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WWM7
Antibodypedia	ATXN2L antibodies

PROTEIN BROWSER

ATXN2L-001	ATXN2L-002	ATXN2L-003	ATXN2L-004	ATXN2L-005	ATXN2L-006	ATXN2L-008	ATXN2L-011	ATXN2L-013	ATXN2L-016	ATXN2L-017	ATXN2L-024	ATXN2L-026	ATXN2L-027

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATXN2L-001 ENSP00000341459 ENST00000340394	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1044 aa 110.3 kDa	No	0
ATXN2L-002 ENSP00000378917 ENST00000395547	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1097 aa 115.6 kDa	No	0
ATXN2L-003 ENSP00000338718 ENST00000336783	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1075 aa 113.4 kDa	No	0
ATXN2L-004 ENSP00000372133 ENST00000382686	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1044 aa 110.1 kDa	No	0
ATXN2L-005 ENSP00000315650 ENST00000325215	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1062 aa 111.9 kDa	No	0
ATXN2L-006 ENSP00000454516 ENST00000570200	Q8WWM7 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0010494 [cytoplasmic stress granule] GO:0010603 [regulation of cytoplasmic mRNA processing body assembly] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0034063 [stress granule assembly] GO:0044822 [poly(A) RNA binding] Show all	1062 aa 112.1 kDa	No	0
ATXN2L-008 ENSP00000457613 ENST00000564304	H3BUF6 [Direct mapping] Ataxin-2-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	1068 aa 112.7 kDa	No	0
ATXN2L-011 ENSP00000454757 ENST00000566946	A0A0C4DGL7 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		401 aa 41.8 kDa	No	0
ATXN2L-013 ENSP00000456752 ENST00000568266	H3BSK9 [Direct mapping] Ataxin-2-like protein Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		336 aa 37.1 kDa	No	0
ATXN2L-016 ENSP00000456812 ENST00000564656	H3BSQ5 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 10.1 kDa	No	0
ATXN2L-017 ENSP00000455981 ENST00000566007	H3BQX7 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 13 kDa	No	0
ATXN2L-024 ENSP00000454588 ENST00000569318	H3BMX1 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		187 aa 19.1 kDa	No	0
ATXN2L-026 ENSP00000455560 ENST00000567024	H3BQ14 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		11 aa 1 kDa	No	0
ATXN2L-027 ENSP00000455427 ENST00000564162	H3BPQ7 [Direct mapping] Ataxin-2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.