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Signal transducer and activator of transcription 3 (acute-phase response factor) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
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Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001659 [temperature homeostasis] GO:0001754 [eye photoreceptor cell differentiation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004871 [signal transducer activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006606 [protein import into nucleus] GO:0006928 [movement of cell or subcellular component] GO:0006953 [acute-phase response] GO:0007165 [signal transduction] GO:0007259 [JAK-STAT cascade] GO:0007399 [nervous system development] GO:0007568 [aging] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0010033 [response to organic substance] GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process] GO:0014070 [response to organic cyclic compound] GO:0016032 [viral process] GO:0016310 [phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019827 [stem cell population maintenance] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0019953 [sexual reproduction] GO:0030522 [intracellular receptor signaling pathway] GO:0031730 [CCR5 chemokine receptor binding] GO:0032355 [response to estradiol] GO:0032870 [cellular response to hormone stimulus] GO:0034097 [response to cytokine] GO:0035019 [somatic stem cell population maintenance] GO:0035259 [glucocorticoid receptor binding] GO:0040014 [regulation of multicellular organism growth] GO:0042493 [response to drug] GO:0042593 [glucose homeostasis] GO:0042755 [eating behavior] GO:0043066 [negative regulation of apoptotic process] GO:0043434 [response to peptide hormone] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045471 [response to ethanol] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045820 [negative regulation of glycolytic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046902 [regulation of mitochondrial membrane permeability] GO:0046983 [protein dimerization activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048708 [astrocyte differentiation] GO:0060019 [radial glial cell differentiation] GO:0060396 [growth hormone receptor signaling pathway] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0060548 [negative regulation of cell death] GO:0070102 [interleukin-6-mediated signaling pathway] GO:0071345 [cellular response to cytokine stimulus] GO:0071407 [cellular response to organic cyclic compound] GO:0090575 [RNA polymerase II transcription factor complex] GO:1901215 [negative regulation of neuron death] GO:1902728 [positive regulation of growth factor dependent skeletal muscle satellite cell proliferation] GO:2001171 [positive regulation of ATP biosynthetic process] GO:2001223 [negative regulation of neuron migration]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
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Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001659 [temperature homeostasis] GO:0001754 [eye photoreceptor cell differentiation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004871 [signal transducer activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006606 [protein import into nucleus] GO:0006928 [movement of cell or subcellular component] GO:0007165 [signal transduction] GO:0007259 [JAK-STAT cascade] GO:0007399 [nervous system development] GO:0008134 [transcription factor binding] GO:0016032 [viral process] GO:0016310 [phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0019953 [sexual reproduction] GO:0030522 [intracellular receptor signaling pathway] GO:0032355 [response to estradiol] GO:0032870 [cellular response to hormone stimulus] GO:0035019 [somatic stem cell population maintenance] GO:0042593 [glucose homeostasis] GO:0042755 [eating behavior] GO:0043066 [negative regulation of apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048708 [astrocyte differentiation] GO:0060019 [radial glial cell differentiation] GO:0060396 [growth hormone receptor signaling pathway] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0070102 [interleukin-6-mediated signaling pathway] GO:0090575 [RNA polymerase II transcription factor complex]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
Show all
Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001659 [temperature homeostasis] GO:0001754 [eye photoreceptor cell differentiation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004871 [signal transducer activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006606 [protein import into nucleus] GO:0006928 [movement of cell or subcellular component] GO:0007165 [signal transduction] GO:0007259 [JAK-STAT cascade] GO:0007399 [nervous system development] GO:0008134 [transcription factor binding] GO:0016032 [viral process] GO:0016310 [phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0019953 [sexual reproduction] GO:0030522 [intracellular receptor signaling pathway] GO:0032355 [response to estradiol] GO:0032870 [cellular response to hormone stimulus] GO:0035019 [somatic stem cell population maintenance] GO:0042593 [glucose homeostasis] GO:0042755 [eating behavior] GO:0043066 [negative regulation of apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048708 [astrocyte differentiation] GO:0060019 [radial glial cell differentiation] GO:0060396 [growth hormone receptor signaling pathway] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0070102 [interleukin-6-mediated signaling pathway] GO:0090575 [RNA polymerase II transcription factor complex]
G8JLH9 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014)
K7EP08 [Direct mapping] Signal transducer and activator of transcription 3
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014)