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PLA2G4F

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GENERAL INFORMATION

Gene name

 PLA2G4F

Gene description

 Phospholipase A2, group IVF

Protein class

 Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to vesicles. In addition localized to the nucleus.

RNA cell category

 Cell line enhanced (RT4, hTCEpi)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved)

Additional location

 In addition localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA042713
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, hTCEpi)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to vesicles. In addition localized to the nucleus.

Main location

 Vesicles (approved)

Additional location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA042713 RT4 Nucleus
Vesicles
HPA042713 U-2 OS No staining    
HPA042713 U-251 MG No staining    

GENE INFORMATION

Gene name

 PLA2G4F (HGNC Symbol)

Synonyms

 PLA2G4F/Z

Description

 Phospholipase A2, group IVF (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 42139034 - 42156636

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168907 (version 83.38)

Entrez gene

 255189

UniProt

 Q68DD2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q68DD2

Antibodypedia

 PLA2G4F antibodies

PROTEIN BROWSER
PLA2G4F-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLA2G4F-001
ENSP00000380442
ENST00000397272
Q68DD2 [Direct mapping]
Cytosolic phospholipase A2 zeta
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001516 [prostaglandin biosynthetic process]
GO:0004620 [phospholipase activity]
GO:0004622 [lysophospholipase activity]
GO:0004623 [phospholipase A2 activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006644 [phospholipid metabolic process]
GO:0008152 [metabolic process]
GO:0009395 [phospholipid catabolic process]
GO:0015908 [fatty acid transport]
GO:0031982 [vesicle]
GO:0032587 [ruffle membrane]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036149 [phosphatidylinositol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0046872 [metal ion binding]
GO:0047498 [calcium-dependent phospholipase A2 activity]
GO:0050482 [arachidonic acid secretion]
GO:0071236 [cellular response to antibiotic]
GO:0071407 [cellular response to organic cyclic compound]
Show all
 849 aa
95.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.