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Cytoplasmic positivity often with a granular pattern at varying intensities was displayed in several cases of most cancer tissues. Moderate nuclear staining was observed in urothelial cancers. Melanomas and lymphomas were negative.
The protein encoded by this gene belongs to the sperm-coating protein family of epididymal origin. This protein and its canine homolog are the first known examples of proteins with four tandemly arranged fibronectin type 2 (Fn2) domains in the Fn2-module protein family. [provided by RefSeq, Jul 2008]