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CHRNA5

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GENERAL INFORMATION

Gene name

 CHRNA5

Gene description

 Cholinergic receptor, nicotinic, alpha 5 (neuronal)

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the focal adhesion sites. In addition localized to the plasma membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Focal adhesion sites (approved)

Additional location

 In addition localized to the Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA054381
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the focal adhesion sites. In addition localized to the plasma membrane.

Main location

 Focal adhesion sites (approved)

Additional location

 Plasma membrane (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA054381 A-431 Focal adhesion sites
HPA054381 U-2 OS Plasma membrane
Focal adhesion sites

GENE INFORMATION

Gene name

 CHRNA5

Synonyms

Description

 Cholinergic receptor, nicotinic, alpha 5 (neuronal) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]

Chromosome

 15

Cytoband

 q25.1

Chromosome location (bp)

 78565520 - 78595269

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169684 (version 83.38)

Entrez gene

 1138

UniProt

 P30532 (UniProt - Evidence at protein level)

neXtProt

 NX_P30532

Antibodypedia

 CHRNA5 antibodies

PROTEIN BROWSER
CHRNA5-001
CHRNA5-002
CHRNA5-003
CHRNA5-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHRNA5-001
ENSP00000299565
ENST00000299565
P30532 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005892 [acetylcholine-gated channel complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007274 [neuromuscular synaptic transmission]
GO:0015276 [ligand-gated ion channel activity]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035094 [response to nicotine]
GO:0035095 [behavioral response to nicotine]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046982 [protein heterodimerization activity]
GO:0050877 [neurological system process]
GO:0098655 [cation transmembrane transport]
Show all
 468 aa
53.1 kDa 		Yes 4
CHRNA5-002
ENSP00000378281
ENST00000394802
H7BYM0 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-5
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Predicted intracellular proteins
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0045211 [postsynaptic membrane]
GO:0098655 [cation transmembrane transport]
Show all
 182 aa
20.7 kDa 		No 0
CHRNA5-003
ENSP00000453519
ENST00000559554
H0YM98 [Direct mapping]
Cholinergic receptor, nicotinic, alpha 5, isoform CRA_b; Neuronal acetylcholine receptor subunit alpha-5
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0045211 [postsynaptic membrane]
GO:0098655 [cation transmembrane transport]
Show all
 160 aa
17.8 kDa 		Yes 0
CHRNA5-004
ENSP00000452641
ENST00000559576
H0YK34 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-5
Show all
Predicted intracellular proteins
Show all
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 56 aa
6.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.