Fields »
ABOUT
HELP
BLOG
CHRNA5

GENERAL INFORMATION

Gene name

 CHRNA5

Gene description

 Cholinergic receptor, nicotinic, alpha 5 (neuronal)

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (vagina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several tissues, including processes in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Nuclear staining viewed as off target and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA054381
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (vagina)

GENE INFORMATION

Gene name

 CHRNA5

Synonyms

Description

 Cholinergic receptor, nicotinic, alpha 5 (neuronal) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]

Chromosome

 15

Cytoband

 q25.1

Chromosome location (bp)

 78565520 - 78595269

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169684 (version 83.38)

Entrez gene

 1138

UniProt

 P30532 (UniProt - Evidence at protein level)

neXtProt

 NX_P30532

Antibodypedia

 CHRNA5 antibodies

PROTEIN BROWSER
CHRNA5-001
CHRNA5-002
CHRNA5-003
CHRNA5-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHRNA5-001
ENSP00000299565
ENST00000299565
P30532 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005892 [acetylcholine-gated channel complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007274 [neuromuscular synaptic transmission]
GO:0015276 [ligand-gated ion channel activity]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035094 [response to nicotine]
GO:0035095 [behavioral response to nicotine]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046982 [protein heterodimerization activity]
GO:0050877 [neurological system process]
GO:0098655 [cation transmembrane transport]
Show all
 468 aa
53.1 kDa 		Yes 4
CHRNA5-002
ENSP00000378281
ENST00000394802
H7BYM0 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-5
Show all
Predicted intracellular proteins
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0045211 [postsynaptic membrane]
GO:0098655 [cation transmembrane transport]
Show all
 182 aa
20.7 kDa 		No 0
CHRNA5-003
ENSP00000453519
ENST00000559554
H0YM98 [Direct mapping]
Cholinergic receptor, nicotinic, alpha 5, isoform CRA_b; Neuronal acetylcholine receptor subunit alpha-5
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0045211 [postsynaptic membrane]
GO:0098655 [cation transmembrane transport]
Show all
 160 aa
17.8 kDa 		Yes 0
CHRNA5-004
ENSP00000452641
ENST00000559576
H0YK34 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-5
Show all
Predicted intracellular proteins
Show all
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 56 aa
6.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.