Expression of CTNND2 in cancer - Summary

CANCER ATLAS

Gene description

Catenin (cadherin-associated protein), delta 2

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA015077	CAB037339

GENE INFORMATION
Gene name	CTNND2 (HGNC Symbol)
Synonyms	GT24, NPRAP
Description	Catenin (cadherin-associated protein), delta 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Chromosome	5
Cytoband	p15.2
Chromosome location (bp)	10971840 - 11904043
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169862 (version 83.38)
Entrez gene	1501
UniProt	Q9UQB3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UQB3
Antibodypedia	CTNND2 antibodies

PROTEIN BROWSER

CTNND2-001	CTNND2-004	CTNND2-005	CTNND2-008	CTNND2-009	CTNND2-012	CTNND2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTNND2-001 ENSP00000307134 ENST00000304623	Q9UQB3 [Direct mapping] Catenin delta-2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001763 [morphogenesis of a branching structure] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005912 [adherens junction] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007612 [learning] GO:0008013 [beta-catenin binding] GO:0014069 [postsynaptic density] GO:0016055 [Wnt signaling pathway] GO:0016337 [single organismal cell-cell adhesion] GO:0030425 [dendrite] GO:0043005 [neuron projection] GO:0043204 [perikaryon] GO:0048167 [regulation of synaptic plasticity] GO:0050808 [synapse organization] GO:0060828 [regulation of canonical Wnt signaling pathway] GO:0060997 [dendritic spine morphogenesis] Show all	1225 aa 132.7 kDa	No	0
CTNND2-004 ENSP00000426887 ENST00000503622	B4DRK2 [Direct mapping] Catenin delta-2; cDNA FLJ56233, highly similar to Catenin delta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0016337 [single organismal cell-cell adhesion] Show all	888 aa 98 kDa	No	0
CTNND2-005 ENSP00000426510 ENST00000511377	E7EPC8 [Direct mapping] Catenin delta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0016337 [single organismal cell-cell adhesion] Show all	1134 aa 123.1 kDa	No	0
CTNND2-008 ENSP00000424296 ENST00000508761	D6RBA8 [Direct mapping] Catenin delta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016337 [single organismal cell-cell adhesion] Show all	169 aa 18.4 kDa	No	0
CTNND2-009 ENSP00000422389 ENST00000502551	D6RC65 [Direct mapping] Catenin delta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016337 [single organismal cell-cell adhesion] Show all	209 aa 22.7 kDa	No	0
CTNND2-012 ENSP00000426625 ENST00000513598	D6RF55 [Direct mapping] Catenin delta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016337 [single organismal cell-cell adhesion] Show all	181 aa 18.9 kDa	No	0
CTNND2-201 ENSP00000391155 ENST00000458100	D6R9A8 [Direct mapping] Catenin delta-2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0016337 [single organismal cell-cell adhesion] Show all	320 aa 35.8 kDa	No	0