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CTNND2

GENERAL INFORMATION

Gene name

 CTNND2

Gene description

 Catenin (cadherin-associated protein), delta 2

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebral cortex, caudate, hippocampus, hypothalamus, cerebellum)
FANTOM5:Tissue enhanced (hippocampus, caudate, cerebellum, brain)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression mainly in the CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA015077 , CAB037339
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, caudate, hippocampus, hypothalamus, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hippocampus, caudate, cerebellum, brain)

GENE INFORMATION

Gene name

 CTNND2 (HGNC Symbol)

Synonyms

 GT24, NPRAP

Description

 Catenin (cadherin-associated protein), delta 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

Chromosome

 5

Cytoband

 p15.2

Chromosome location (bp)

 10971840 - 11904043

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169862 (version 83.38)

Entrez gene

 1501

UniProt

 Q9UQB3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQB3

Antibodypedia

 CTNND2 antibodies

PROTEIN BROWSER
CTNND2-001
CTNND2-004
CTNND2-005
CTNND2-008
CTNND2-009
CTNND2-012
CTNND2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTNND2-001
ENSP00000307134
ENST00000304623
Q9UQB3 [Direct mapping]
Catenin delta-2
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001763 [morphogenesis of a branching structure]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007612 [learning]
GO:0008013 [beta-catenin binding]
GO:0014069 [postsynaptic density]
GO:0016055 [Wnt signaling pathway]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030425 [dendrite]
GO:0043005 [neuron projection]
GO:0043204 [perikaryon]
GO:0048167 [regulation of synaptic plasticity]
GO:0050808 [synapse organization]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0060997 [dendritic spine morphogenesis]
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 1225 aa
132.7 kDa 		No 0
CTNND2-004
ENSP00000426887
ENST00000503622
B4DRK2 [Direct mapping]
Catenin delta-2; cDNA FLJ56233, highly similar to Catenin delta-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0016337 [single organismal cell-cell adhesion]
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 888 aa
98 kDa 		No 0
CTNND2-005
ENSP00000426510
ENST00000511377
E7EPC8 [Direct mapping]
Catenin delta-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0016337 [single organismal cell-cell adhesion]
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 1134 aa
123.1 kDa 		No 0
CTNND2-008
ENSP00000424296
ENST00000508761
D6RBA8 [Direct mapping]
Catenin delta-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016337 [single organismal cell-cell adhesion]
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 169 aa
18.4 kDa 		No 0
CTNND2-009
ENSP00000422389
ENST00000502551
D6RC65 [Direct mapping]
Catenin delta-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016337 [single organismal cell-cell adhesion]
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 209 aa
22.7 kDa 		No 0
CTNND2-012
ENSP00000426625
ENST00000513598
D6RF55 [Direct mapping]
Catenin delta-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016337 [single organismal cell-cell adhesion]
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 181 aa
18.9 kDa 		No 0
CTNND2-201
ENSP00000391155
ENST00000458100
D6R9A8 [Direct mapping]
Catenin delta-2
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0016337 [single organismal cell-cell adhesion]
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 320 aa
35.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.