Expression of SERPINA6 in cancer - Summary

CANCER ATLAS

Gene description

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6

Protein class

Disease related genes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017864

GENE INFORMATION
Gene name	SERPINA6 (HGNC Symbol)
Synonyms	CBG
Description	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (HGNC Symbol)
Entrez gene summary	This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.13
Chromosome location (bp)	94304248 - 94323394
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170099 (version 83.38)
Entrez gene	866
UniProt	P08185 (UniProt - Evidence at protein level)
neXtProt	NX_P08185
Antibodypedia	SERPINA6 antibodies

PROTEIN BROWSER

SERPINA6-001	SERPINA6-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINA6-001 ENSP00000342850 ENST00000341584	P08185 [Direct mapping] Corticosteroid-binding globulin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005496 [steroid binding] GO:0005615 [extracellular space] GO:0006810 [transport] GO:0008211 [glucocorticoid metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	405 aa 45.1 kDa	Yes	0
SERPINA6-004 ENSP00000452018 ENST00000557225	G3V4V7 [Direct mapping] Corticosteroid-binding globulin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	136 aa 15 kDa	Yes	0