Cell atlas - SERPINA6 - The Human Protein Atlas

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SERPINA6

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SERPINA6
Gene description	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (T-47d)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (T-47d) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SERPINA6 (HGNC Symbol)
Synonyms	CBG
Description	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (HGNC Symbol)
Entrez gene summary	This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.13
Chromosome location (bp)	94304248 - 94323394
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170099 (version 83.38)
Entrez gene	866
UniProt	P08185 (UniProt - Evidence at protein level)
neXtProt	NX_P08185
Antibodypedia	SERPINA6 antibodies

PROTEIN BROWSER

SERPINA6-001	SERPINA6-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINA6-001 ENSP00000342850 ENST00000341584	P08185 [Direct mapping] Corticosteroid-binding globulin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005496 [steroid binding] GO:0005615 [extracellular space] GO:0006810 [transport] GO:0008211 [glucocorticoid metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	405 aa 45.1 kDa	Yes	0
SERPINA6-004 ENSP00000452018 ENST00000557225	G3V4V7 [Direct mapping] Corticosteroid-binding globulin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	136 aa 15 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.