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SERPINA6

GENERAL INFORMATION

Gene name

 SERPINA6

Gene description

 Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Secreted positivity in several tissue types.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
HPA017864
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 SERPINA6 (HGNC Symbol)

Synonyms

 CBG

Description

 Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q32.13

Chromosome location (bp)

 94304248 - 94323394

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170099 (version 83.38)

Entrez gene

 866

UniProt

 P08185 (UniProt - Evidence at protein level)

neXtProt

 NX_P08185

Antibodypedia

 SERPINA6 antibodies

PROTEIN BROWSER
SERPINA6-001
SERPINA6-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SERPINA6-001
ENSP00000342850
ENST00000341584
P08185 [Direct mapping]
Corticosteroid-binding globulin
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005496 [steroid binding]
GO:0005615 [extracellular space]
GO:0006810 [transport]
GO:0008211 [glucocorticoid metabolic process]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0070062 [extracellular exosome]
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 405 aa
45.1 kDa 		Yes 0
SERPINA6-004
ENSP00000452018
ENST00000557225
G3V4V7 [Direct mapping]
Corticosteroid-binding globulin
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 136 aa
15 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.