Expression of FRMPD2 in cancer - Summary

CANCER ATLAS

Gene description

FERM and PDZ domain containing 2

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA045059

GENE INFORMATION
Gene name	FRMPD2 (HGNC Symbol)
Synonyms	MGC35285, PDZD5C, PDZK5C
Description	FERM and PDZ domain containing 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]
Chromosome	10
Cytoband	q11.22
Chromosome location (bp)	48156558 - 48274870
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170324 (version 83.38)
Entrez gene	143162
UniProt	Q68DX3 (UniProt - Evidence at protein level)
neXtProt	NX_Q68DX3
Antibodypedia	FRMPD2 antibodies

PROTEIN BROWSER

FRMPD2-001	FRMPD2-005	FRMPD2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FRMPD2-001 ENSP00000363317 ENST00000374201	Q68DX3 [Direct mapping] FERM and PDZ domain-containing protein 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005923 [bicellular tight junction] GO:0016323 [basolateral plasma membrane] GO:0070830 [bicellular tight junction assembly] Show all	1309 aa 144.3 kDa	No	0
FRMPD2-005 ENSP00000307079 ENST00000305531	Q68DX3 [Direct mapping] FERM and PDZ domain-containing protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005923 [bicellular tight junction] GO:0016323 [basolateral plasma membrane] GO:0070830 [bicellular tight junction assembly] Show all	1284 aa 141.5 kDa	Yes	0
FRMPD2-007 ENSP00000422446 ENST00000474573	Q68DX3 [Direct mapping] FERM and PDZ domain-containing protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005923 [bicellular tight junction] GO:0016323 [basolateral plasma membrane] GO:0070830 [bicellular tight junction assembly] Show all	261 aa 28.8 kDa	No	0