Tissue expression of FRMPD2 - Summary - The Human Protein Atlas

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FRMPD2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FRMPD2
Gene description	FERM and PDZ domain containing 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (fallopian tube, cerebral cortex, testis)
GTEx:	Tissue enhanced (testis)
FANTOM5:	Tissue enhanced (retina, caudate, epididymis)

Protein evidence

Evidence at protein level

Protein expression

RNA-based expert annotation gave inconclusive results.

DATA RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA045059
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (fallopian tube, cerebral cortex, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (retina, caudate, epididymis)

GENE INFORMATION
Gene name	FRMPD2 (HGNC Symbol)
Synonyms	MGC35285, PDZD5C, PDZK5C
Description	FERM and PDZ domain containing 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]
Chromosome	10
Cytoband	q11.22
Chromosome location (bp)	48156558 - 48274870
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170324 (version 83.38)
Entrez gene	143162
UniProt	Q68DX3 (UniProt - Evidence at protein level)
neXtProt	NX_Q68DX3
Antibodypedia	FRMPD2 antibodies

PROTEIN BROWSER

FRMPD2-001	FRMPD2-005	FRMPD2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FRMPD2-001 ENSP00000363317 ENST00000374201	Q68DX3 [Direct mapping] FERM and PDZ domain-containing protein 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005923 [bicellular tight junction] GO:0016323 [basolateral plasma membrane] GO:0070830 [bicellular tight junction assembly] Show all	1309 aa 144.3 kDa	No	0
FRMPD2-005 ENSP00000307079 ENST00000305531	Q68DX3 [Direct mapping] FERM and PDZ domain-containing protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005923 [bicellular tight junction] GO:0016323 [basolateral plasma membrane] GO:0070830 [bicellular tight junction assembly] Show all	1284 aa 141.5 kDa	Yes	0
FRMPD2-007 ENSP00000422446 ENST00000474573	Q68DX3 [Direct mapping] FERM and PDZ domain-containing protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005923 [bicellular tight junction] GO:0016323 [basolateral plasma membrane] GO:0070830 [bicellular tight junction assembly] Show all	261 aa 28.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.