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FRMPD2

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GENERAL INFORMATION

Gene name

 FRMPD2

Gene description

 FERM and PDZ domain containing 2

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (BEWO, SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO, SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 FRMPD2 (HGNC Symbol)

Synonyms

 MGC35285, PDZD5C, PDZK5C

Description

 FERM and PDZ domain containing 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]

Chromosome

 10

Cytoband

 q11.22

Chromosome location (bp)

 48156558 - 48274870

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170324 (version 83.38)

Entrez gene

 143162

UniProt

 Q68DX3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q68DX3

Antibodypedia

 FRMPD2 antibodies

PROTEIN BROWSER
FRMPD2-001
FRMPD2-005
FRMPD2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FRMPD2-001
ENSP00000363317
ENST00000374201
Q68DX3 [Direct mapping]
FERM and PDZ domain-containing protein 2
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005923 [bicellular tight junction]
GO:0016323 [basolateral plasma membrane]
GO:0070830 [bicellular tight junction assembly]
Show all
 1309 aa
144.3 kDa 		No 0
FRMPD2-005
ENSP00000307079
ENST00000305531
Q68DX3 [Direct mapping]
FERM and PDZ domain-containing protein 2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005923 [bicellular tight junction]
GO:0016323 [basolateral plasma membrane]
GO:0070830 [bicellular tight junction assembly]
Show all
 1284 aa
141.5 kDa 		Yes 0
FRMPD2-007
ENSP00000422446
ENST00000474573
Q68DX3 [Direct mapping]
FERM and PDZ domain-containing protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005923 [bicellular tight junction]
GO:0016323 [basolateral plasma membrane]
GO:0070830 [bicellular tight junction assembly]
Show all
 261 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.