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OTP

GENERAL INFORMATION

Gene name

 OTP

Gene description

 Orthopedia homeobox

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Tissue enriched (hypothalamus)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA039365
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (hypothalamus)

GENE INFORMATION

Gene name

 OTP

Synonyms

Description

 Orthopedia homeobox (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q14.1

Chromosome location (bp)

 77628712 - 77639688

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171540 (version 83.38)

Entrez gene

 23440

UniProt

 Q5XKR4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5XKR4

Antibodypedia

 OTP antibodies

PROTEIN BROWSER
OTP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OTP-001
ENSP00000302814
ENST00000306422
Q5XKR4 [Direct mapping]
Homeobox protein orthopedia
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0021879 [forebrain neuron differentiation]
GO:0021979 [hypothalamus cell differentiation]
GO:0021985 [neurohypophysis development]
GO:0043565 [sequence-specific DNA binding]
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 325 aa
34.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.