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Distinct staining was observed in tumor stroma. A few colorectal-, liver-, urothelial- and pancreatic cancers displayed weak cytoplasmic immunoreactivity. Remaining malignant cells were negative.
Stromal cells and extra cellular material were distinctly stained in most malignancies. Moderate to strong cytoplasmic and/or membranous staining was observed in a fraction of cells in most cases of hepatocellular carcinomas, urothelia, renal, breast and ovarian cancers along with a few cases of most other malignancies. Most malignant cells were however in general weakly stained or negative.
GENE INFORMATION
Gene name
FGB
Synonyms
Description
Fibrinogen beta chain (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]