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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

FGB

Gene description

Fibrinogen beta chain

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in hepatocytes, and strong positivity in plasma and extracellular compartments.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 3 antibodies.
HPA001900 , HPA001901 , CAB008624
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

FGB

Synonyms

Description

Fibrinogen beta chain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Chromosome

4

Cytoband

q31.3

Chromosome location (bp)

154562956 - 154571086

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171564 (version 83.38)

Entrez gene

2244

UniProt

P02675 (UniProt - Evidence at protein level)

neXtProt

NX_P02675

Antibodypedia

FGB antibodies

PROTEIN BROWSER

FGB-001
FGB-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGB-001
ENSP00000306099
ENST00000302068
P02675 [Direct mapping]
Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain
V9HVY1 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 78p
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0002576 [platelet degranulation]
GO:0005102 [receptor binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030674 [protein binding, bridging]
GO:0031091 [platelet alpha granule]
GO:0031093 [platelet alpha granule lumen]
GO:0031639 [plasminogen activation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0042730 [fibrinolysis]
GO:0043152 [induction of bacterial agglutination]
GO:0043623 [cellular protein complex assembly]
GO:0044320 [cellular response to leptin stimulus]
GO:0045087 [innate immune response]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045921 [positive regulation of exocytosis]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051087 [chaperone binding]
GO:0051258 [protein polymerization]
GO:0051592 [response to calcium ion]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071347 [cellular response to interleukin-1]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0090277 [positive regulation of peptide hormone secretion]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903561 [extracellular vesicle]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
491 aa
55.9 kDa
Yes 0
FGB-010
ENSP00000426757
ENST00000509493
D6REL8 [Direct mapping]
Fibrinogen beta chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
272 aa
31.2 kDa
No 0

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