Cell atlas - ATF7IP - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ATF7IP
Gene description	Activating transcription factor 7 interacting protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	20
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated), Nuclear bodies (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA016578 , HPA023505
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies & nucleoplasm.

Main location

Nucleoplasm (validated), Nuclear bodies (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA016578	A-431	Nucleoplasm
		Nuclear bodies
		Cytosol
HPA016578	U-2 OS	Nucleoplasm
		Nuclear bodies
		Cytosol
HPA016578	U-251 MG	Nucleoplasm
HPA016578	U-251 MG	Nuclear bodies
HPA023505	A-431	Nucleoplasm
HPA023505	A-431	Nuclear bodies
HPA023505	U-2 OS	Nucleoplasm
HPA023505	U-2 OS	Nuclear bodies
HPA023505	U-251 MG	Nucleoplasm
HPA023505	U-251 MG	Nuclear bodies

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

HPA023505

siRNA validation

Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

59%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail 10x	Thumbnail 40x	Antibody	Sample	Cell line
		HPA023505	siRNA 1	U-2 OS
		HPA023505	scrambled	U-2 OS

GENE INFORMATION
Gene name	ATF7IP (HGNC Symbol)
Synonyms	FLJ10688, p621
Description	Activating transcription factor 7 interacting protein (HGNC Symbol)
Entrez gene summary	ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]
Chromosome	12
Cytoband	p13.1
Chromosome location (bp)	14365632 - 14502935
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171681 (version 83.38)
Entrez gene	55729
UniProt	Q6VMQ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q6VMQ6
Antibodypedia	ATF7IP antibodies

PROTEIN BROWSER

ATF7IP-001	ATF7IP-002	ATF7IP-004	ATF7IP-008	ATF7IP-009	ATF7IP-010	ATF7IP-011	ATF7IP-012	ATF7IP-013	ATF7IP-014	ATF7IP-015	ATF7IP-016	ATF7IP-018	ATF7IP-019	ATF7IP-020	ATF7IP-021	ATF7IP-022	ATF7IP-023	ATF7IP-024	ATF7IP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATF7IP-001 ENSP00000445955 ENST00000536444	Q6VMQ6 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006306 [DNA methylation] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0016032 [viral process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045898 [regulation of RNA polymerase II transcriptional preinitiation complex assembly] Show all	1269 aa 136.3 kDa	No	0
ATF7IP-002 ENSP00000440440 ENST00000544627	Q6VMQ6 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006306 [DNA methylation] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0016032 [viral process] GO:0016887 [ATPase activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045898 [regulation of RNA polymerase II transcriptional preinitiation complex assembly] Show all	1278 aa 137.5 kDa	No	0
ATF7IP-004 ENSP00000443179 ENST00000543189	Q6VMQ6 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006306 [DNA methylation] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0016032 [viral process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045898 [regulation of RNA polymerase II transcriptional preinitiation complex assembly] Show all	1105 aa 118.7 kDa	No	0
ATF7IP-008 ENSP00000437711 ENST00000535738	H0YFA3 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 12.1 kDa	No	0
ATF7IP-009 ENSP00000445604 ENST00000535132	F5H221 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.9 kDa	No	0
ATF7IP-010 ENSP00000444784 ENST00000542967	F5H502 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	176 aa 18.9 kDa	No	0
ATF7IP-011 ENSP00000439279 ENST00000534828	F5H2W9 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	152 aa 16.7 kDa	No	0
ATF7IP-012 ENSP00000443855 ENST00000542991	F5GZ98 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.8 kDa	No	0
ATF7IP-013 ENSP00000441483 ENST00000541056	F5GZ10 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	169 aa 18.3 kDa	No	0
ATF7IP-014 ENSP00000439578 ENST00000539057	F5H1K9 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	177 aa 19 kDa	No	0
ATF7IP-015 ENSP00000442958 ENST00000536279	F5H6X8 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 10.3 kDa	No	0
ATF7IP-016 ENSP00000439192 ENST00000542508	F5H3C4 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		32 aa 3.8 kDa	No	0
ATF7IP-018 ENSP00000379575 ENST00000396279	A8MV73 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	515 aa 55 kDa	No	0
ATF7IP-019 ENSP00000446260 ENST00000545769	F5H2H9 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	169 aa 18.3 kDa	No	0
ATF7IP-020 ENSP00000444620 ENST00000545723	F5H592 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		143 aa 16.6 kDa	No	0
ATF7IP-021 ENSP00000440587 ENST00000538511	F5GYR7 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 11.4 kDa	No	0
ATF7IP-022 ENSP00000443540 ENST00000542514	F5H8I0 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	132 aa 14.9 kDa	No	0
ATF7IP-023 ENSP00000414158 ENST00000428217	F8WE35 [Direct mapping] Activating transcription factor 7-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	125 aa 14.3 kDa	No	0
ATF7IP-024 ENSP00000444589 ENST00000540793	Q6VMQ6 [Direct mapping] Activating transcription factor 7-interacting protein 1 A0A024RAY1 [Target identity:100%; Query identity:100%] Activating transcription factor 7 interacting protein, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006306 [DNA methylation] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0016032 [viral process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045898 [regulation of RNA polymerase II transcriptional preinitiation complex assembly] Show all	1270 aa 136.4 kDa	No	0
ATF7IP-201 ENSP00000261168 ENST00000261168	Q6VMQ6 [Direct mapping] Activating transcription factor 7-interacting protein 1 A0A024RAY1 [Target identity:100%; Query identity:100%] Activating transcription factor 7 interacting protein, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006306 [DNA methylation] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0016032 [viral process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045898 [regulation of RNA polymerase II transcriptional preinitiation complex assembly] Show all	1270 aa 136.4 kDa	No	0