Expression of SPTLC3 in cancer - Summary

CANCER ATLAS

Gene description

Serine palmitoyltransferase, long chain base subunit 3

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA044247

GENE INFORMATION
Gene name	SPTLC3 (HGNC Symbol)
Synonyms	C20orf38, FLJ11112, hLCB2b, LCB2B, SPTLC2L
Description	Serine palmitoyltransferase, long chain base subunit 3 (HGNC Symbol)
Entrez gene summary	The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT; EC 2.3.1.50), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al., 2006 [PubMed 17023427]). SPT contains 2 main subunits: the common SPTLC1 subunit (MIM 605712) and either SPTLC2 (MIM 605713) or its isoform SPTLC2L (SPTLC3), depending on the tissue in which biosynthesis occurs (Hornemann et al., 2006 [PubMed 17023427]). There are also 2 highly related isoforms of a third subunit, SSSPTA (MIM 613540) and SSSPTB (MIM 610412), that confer acyl-CoA preference of the SPT enzyme and are essential for maximal enzyme activity (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]
Chromosome	20
Cytoband	p12.1
Chromosome location (bp)	13008979 - 13169103
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172296 (version 83.38)
Entrez gene	55304
UniProt	Q9NUV7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NUV7
Antibodypedia	SPTLC3 antibodies

PROTEIN BROWSER

SPTLC3-001	SPTLC3-002	SPTLC3-003	SPTLC3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPTLC3-001 ENSP00000389749 ENST00000434210	B1AKS2 [Direct mapping] Serine palmitoyltransferase 3; Serine palmitoyltransferase, long chain base subunit 2-like (Aminotransferase 2) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008483 [transaminase activity] GO:0016021 [integral component of membrane] Show all	139 aa 16 kDa	No	1
SPTLC3-002 ENSP00000409125 ENST00000450297	B1AKS3 [Direct mapping] Serine palmitoyltransferase 3; Serine palmitoyltransferase, long chain base subunit 2-like (Aminotransferase 2) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008483 [transaminase activity] Show all	215 aa 24.8 kDa	No	1
SPTLC3-003 ENSP00000409760 ENST00000431275	H0Y733 [Direct mapping] Serine palmitoyltransferase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] Show all	121 aa 13.3 kDa	No	0
SPTLC3-006 ENSP00000381968 ENST00000399002	Q9NUV7 [Direct mapping] Serine palmitoyltransferase 3 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004758 [serine C-palmitoyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0008152 [metabolic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016740 [transferase activity] GO:0017059 [serine C-palmitoyltransferase complex] GO:0030148 [sphingolipid biosynthetic process] GO:0030170 [pyridoxal phosphate binding] GO:0044281 [small molecule metabolic process] GO:0046520 [sphingoid biosynthetic process] Show all	552 aa 62 kDa	No	0